Replicative capacity of a cell is strongly correlated with telomere length regulation. Aberrant
lengthening or reduction in the length of telomeres can lead to health anomalies, such as …

Telomerase is a specialized reverse transcriptase conserved throughout almost all
eukaryotic life. It plays a fundamental role in genome maintenance, adding back the …

The telomere is a special functional complex at the end of linear eukaryotic chromosomes,
consisting of tandem repeat DNA sequences and associated proteins. It is essential for …

Background: Telomerase continues to generate substantial attention both because of its
pivotal roles in cellular proliferation and aging and because of its unusual structure and …

Maintenance of functional telomeres, the highly complex nucleo-protein structures, at the
end of linear eukaryotic chromosomes appears to be essential for growth and survival of the …

To date, the major function attributed to telomerase has been the elongation of telomeres.
Recent studies have assigned new biochemical properties to telomerase by implicating a …

Telomeres are nucleoprotein structures found at the ends of linear chromosomes. Telomeric
DNA shortens with each cell division, effectively restricting the proliferative capacity of …

Telomere maintenance in eukaryotes is linked to cellular proliferation capacity. The
telomerase holoenzyme, which maintains telomere length, is a central actor in this process …

Telomerase has fundamental roles in bypassing cellular aging and in cancer progression by
maintaining telomere homeostasis and integrity. However, recent studies have led some …

Telomerase is the enzyme responsible for maintenance of the length of telomeres by
addition of guanine-rich repetitive sequences. Telomerase activity is exhibited in gametes …