The replication of the ends of linear chromosomes, or telomeres, poses unique problems,
which must be solved to maintain genome integrity and to allow cell division to occur. Here …

Telomeres are the physical ends of eukaryotic chromosomes. They protect chromosome
ends from DNA degradation, recombination, and DNA end fusions, and they are important …

Eukaryotic genomes are highly complex and divided into linear chromosomes that require
end protection from unwarranted fusions, recombination, and degradation in order to …

Most eukaryotes stabilize the ends of their linear chromosomes with a telomerase-based
system. Telomerase maintains specific repetitive sequences, which protect chromosome …

The model for telomere shortening at each replication cycle is currently incomplete, and the
exact contribution of the telomeric 3′ overhang to the shortening rate remains unclear …

Telomeres are essential for genomic stability and their dysfunction has been implicated in
cancer and ageing. The most prominent function of the telomeres is to protect chromosome …

The ends of linear eukaryotic chromosomes, telomeres, distinguish natural chromosome
ends from DNA double stranded breaks and thus promote genome stability. Telomeres …

The maintenance of an appropriate number of telomere repeats by telomerase is essential
for proper chromosome protection. The action of telomerase at the telomere terminus is …

Telomere maintenance critically depends on the distinct activities of telomerase, which adds
telomeric repeats to solve the end replication problem, and RTEL1, which dismantles DNA …

The maintenance of the DNA at chromosome ends, the telomeres, depends on conventional
semiconservative replication and on the action of telomerase, a specialized reverse …