TK5048 and its derivatives, AM‐132, AM‐138, and AM‐97, are recently developed
antimitotic (AM) compounds. These 1‐phenylpropenone derivatives induce cell cycle arrest …

A high-throughput screening assay was designed to select compounds that inhibit the
growth of cultured mammalian cells. After screening more than 60,000 compounds, A …

An efficient synthesis of 3, 4-methylenedioxy-5, 4 '-dimethoxy-3 '-amino-Z-stilbene (1c) and
hydrochloride (1d) is reported. The nitrostilbene intermediate 6a was obtained via a Wittig …

Abstract E7010 (N-[2-[(4-hydroxyphenyl) amino]-3pyridinyl]-4-methoxybenzenesulfonamide)
, an orally active sulfonamide antitumor agent that is currently in a Phase I clinical trial …

We have found that the synthetic compound CC-5079 potently inhibits cancer cell growth in
vitro and in vivo by a novel combination of molecular mechanisms. CC-5079 inhibits …

A novel antitumor compound, N‐β‐dimethylaminoethyl 9‐carboxy‐5‐hydroxy‐10‐
methoxybenzo [a]‐phenazine‐6‐carboxamide sodium salt (NC‐190), was evaluated for …

The novel pyrimidinyl pyrazole derivative, 1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-[4-(3-
chlorophenyl)-1-piperazinyl]-1-trans-propene hydrochloride (DZ-3358), was found through …

A series of stilbenes has been prepared and tested for cytotoxicity in the five human cancer
cell lines A-549 non-small cell lung, MCF-7 breast, HT-29 colon, SKMEL-5 melanoma, and …

Drug resistance is a prevalent problem in the treatment of neoplastic disease, and the
effectiveness of many clinically useful drugs is limited by the fact that they are substrates for …

We studied the synergistic activation of rat alveolar macrophages (AM) by cepharanthine
(Ceph.) and OK-432. Rat AM could be rendered much more tumoricidal against Walker-256 …