Human serum albumin (HSA), the most abundant protein in plasma and cerebrospinal fluid,
not only serves as a crucial carrier of various exogenous and endogenous ligands but also …

The aggregation of α-synuclein (AS) is characteristic of Parkinson's disease and other
neurodegenerative synucleinopathies. Interactions with metal ions affect dramatically the …

The aberrant aggregation of α-synuclein (αS), a disordered protein primarily expressed in
neuronal cells, is strongly associated with the underlying mechanisms of Parkinson's …

The aggregation of α-synuclein (αS) is a critical step in the etiology of Parkinson's disease.
Metal ions such as copper and iron have been shown to bind αS, enhancing its fibrillation …

Alterations in metal ion homeostasis appear coupled to neurodegenerative disorders but
mechanisms are unknown. Amyloid formation of the protein α-synuclein in brain cells is a …

Abstract α-Synuclein (αS) is a presynaptic protein whose aggregates are considered as a
hallmark of Parkinson's disease (PD). Although its physiological function is still under …

The aggregation of α-synuclein (AS) is a critical step in the etiology of Parkinson's disease
(PD) and other neurodegenerative synucleinopathies. Protein− metal interactions play a …

α-Synuclein (αSyn) forms amyloid fibrils in the neurons of Parkinson's disease (PD) patients'.
Despite a role for Cu2+ in accelerating αSyn fibril formation, coupled with reports of copper …

Exposure to heavy metals, including arsenic and cadmium, is associated with
neurodegenerative disorders such as Parkinson's disease. However, the mechanistic details …

Metal ions present in cellular microenvironment have been implicated as drivers of
aggregation of amyloid forming proteins. Zinc (Zn 2+) ions have been reported to directly …