Short-term protein-calorie dietary restriction (StDR) is a promising preoperative strategy for
modulating postoperative inflammation. We have previously shown marked gut microbial …

Intestinal inflammation shifts microbiota composition and metabolism. How the host monitors
and responds to such changes remains unclear. Here, we describe a protective mechanism …

Short-term dietary restriction has been proposed as an intriguing pre-operative conditioning
strategy designed to attenuate the surgical stress response and improve outcomes …

Commensal microbiota promote mucosal tolerance in part by engaging regulatory T (Treg)
cells via Toll-like receptors (TLRs). We report that Treg-cell-specific deletion of the TLR …

A common finding when measuring T cell immunity to enteric bacterial vaccines in humans
is the presence of background responses among individuals before immunization. Yet the …

Inflammatory bowel diseases are characterized by a deregulated immune response
targeting the gut bacterial flora. Mucosal-associated invariant T (MAIT) cells are major …

Mild or transient dietary restriction (DR) improves many aspects of health and aging.
Emerging evidence from us and others has demonstrated that DR also optimizes the …

An important subtype of the innate-like T lymphocytes is mucosal-associated invariant T
(MAIT) cells expressing a semi-invariant T cell receptor α (TCR-α) chain. MAIT cells could be …

Mammals harbor a dense commensal microbiota in the colon. Regulatory T (Treg) cells are
known to limit microbe-triggered intestinal inflammation and the CD4+ T cell compartment is …

Mucosal-associated invariant T (MAIT) cells are innate-like T cells that can activate either in
response to T-cell receptor (TCR) engagement or through activating cytokines and play an …