Oxidatively generated damage to DNA has been implicated in the pathogenesis of a wide
variety of diseases. Increasingly, interest is also focusing upon the effects of damage to the …

During the last three decades there was an increasing interest for developing biomarkers of
oxidative stress. Therefore, efforts have been made to develop sensitive methods aimed at …

Oxidative-stress-induced damage to DNA includes a multitude of lesions, many of which are
mutagenic and have multiple roles in cancer and aging. Many lesions have been …

DNA damage is any modification to the structure of DNA that alters its coding properties
and/or interferes with cell processes. One major consequence of oxidative stress is DNA …

Oxidative damage to DNA is the seemingly inevitable consequence of cellular metabolism.
Furthermore, despite protective mechanisms, cellular levels of damage may increase under …

The analysis of oxidized nucleic acid metabolites can be performed by a variety of
methodologies: liquid chromatography coupled with electrochemical or mass-spectrometry …

Oxidative DNA damage has been implicated to be important in the pathogenesis of many
diseases, including cancer and heart disease. The assessment of damage in various …

Background: Oxidatively generated damage to DNA has been implicated in the
pathogenesis of a wide variety of diseases. The noninvasive assessment of such damage …

Research of the role of oxidative DNA damage is well established in experimental
carcinogenesis. A large number of human studies on biomarkers of oxidative DNA damage …

Oxidative DNA damage is an inevitable consequence of cellular metabolism, with a
propensity for increased levels following toxic insult. Although more than 20 base lesions …