Mitochondrial permeability transition (mPT) is a phenomenon that abruptly causes the flux of
low molecular weight solutes (molecular weight up to 1,500) across the generally …

In this review, we summarize current knowledge of perhaps one of the most intriguing
phenomena in cell biology: the mitochondrial permeability transition pore (mPTP). This …

Permeabilization of the mitochondrial membranes is a crucial step in apoptosis and
necrosis. This phenomenon allows the release of mitochondrial death factors, which trigger …

Several insults cause the inner mitochondrial membrane to abruptly lose osmotic
homeostasis, hence initiating a regulated variant of cell death known as 'mitochondrial …

Bioenergetic failure often features programmed cell death involved in some severe
pathologies. When the cell is fated to die, the inner mitochondrial membrane becomes …

Mitochondrial permeability transition (MPT) is the sudden loss in the permeability of the
inner mitochondrial membrane (IMM) to low-molecular-weight solutes. Due to osmotic …

The mitochondrial permeability transition (mPT) describes a Ca2+-dependent and
cyclophilin D (CypD)-facilitated increase of inner mitochondrial membrane permeability that …

Ion transport across the mitochondrial inner and outer membranes is central to mitochondrial
function, including regulation of oxidative phosphorylation and cell death. Although essential …

Current research on the mitochondrial permeability transition pore (PTP) and its role in cell
death faces a paradox. Initially considered as an in vitro artifact of little pathophysiological …

The mitochondrial permeability transition pore (MPTP) is a calcium-dependent, ion non-
selective membrane pore with a wide range of functions. Although the MPTP has been …