Hepatic fibrosis is a dynamic process characterized by the net accumulation of extracellular
matrix resulting from chronic liver injury of any aetiology, including viral infection, alcoholic …

Activated hepatic stellate cells (aHSC) are the main source of extra cellular matrix in liver
fibrosis. Activation is classically divided in two phases: initiation and perpetuation. Currently …

Hepatic fibrosis is an outcome of many chronic liver diseases, such as viral and autoimmune
hepatitis, and of alcohol consumption and biliary obstruction. Prolonged liver injury results in …

Hepatic fibrosis is characterized by the pathological accumulation of extracellular matrix
(ECM) in the liver resulting from the persistent liver injury and wound-healing reaction …

The last decade has seen a rapid expansion in our understanding of the mechanisms
leading to hepatic stellate cell activation. The classic activation pathway of initiation …

Liver fibrosis is a dynamic wound-healing process characterized by the net accumulation of
extracellular matrix. There is no efficient antifibrotic therapy other than liver transplantation to …

Hepatic stellate cells (HSCs) comprise a minor cell population in the liver but serve
numerous critical functions in the normal liver and in response to injury. HSCs are primarily …

Activation of hepatic stellate cells (HSCs) is the dominant event in liver fibrosis. The early
events in the organization of HSC activation have been termed initiation. Initiation …

Hepatic fibrosis is a wound‐healing response to chronic liver injury, which if persistent leads
to cirrhosis and liver failure. Exciting progress has been made in understanding the …

Hepatic fibrosis is a wound-healing process that occurs when the liver is injured chronically.
Hepatic stellate cells (HSC) are responsible for the excess production of extracellular matrix …