The neural mechanisms underlying the development and maintenance of chronic
neuropathic pain remain unclear. Evidence from human investigations suggests that …

Human brain imaging has revealed that acute pain results from activation of a network of
brain regions, including the somatosensory, insular, prefrontal, and cingulate cortices. In …

Pain is a complex phenomenon that is served by neural oscillations and connectivity
involving different brain areas and frequencies. Here, we aimed to systematically and …

Pain is a complex perceptual phenomenon. Coordinated activity among local and distant
brain networks is a central element of the neural underpinnings of pain. Brain oscillatory …

Reports of more than a century of medical observation and research have demonstrated that
neuropathic pain is more definitive than merely a concept or a single disorder: It is instead …

It is largely acknowledged that multiple and complex pathophysiological mechanisms may
be at play in neuropathic pain. This short review summarises the current understanding of …

Background: The management of chronic pain represents a significant public health issue in
the United States. It is both costly to our health care system and devastating to the patient's …

Noxious stimuli induce physiological processes which commonly translate into pain.
However, under certain conditions, pain intensity can substantially dissociate from stimulus …

Neural oscillations play an important role in the integration and segregation of brain regions
that are important for brain functions, including pain. Disturbances in oscillatory activity are …

The past decade has seen great progress in understanding its causes and in finding new
drugs that promise great benefit. An early outcome of the research has been the observation …