Iron is a transition metal utilized by nearly all forms of life for essential cellular processes,
such as DNA synthesis and cellular respiration. During infection by bacterial pathogens, the …

Bacteria that reside in animal tissues and/or cells must acquire iron from their host. However,
almost all of the host iron is sequestered in iron-containing compounds and proteins, the …

Iron is essential for the survival of most bacteria but presents a significant challenge given its
limited bioavailability. Furthermore, the toxicity of iron combined with the need to maintain …

Covering: 2000–2006 The ability of bacterial pathogens to obtain iron is essential for their
survival, and the expression of such virulence factors is (in part) essential for establishing …

Iron is a versatile redox-active catalyst and a required cofactor within a diverse array of
biological processes. To almost all organisms, iron is both essential and potentially toxic …

Bacterial pathogens require the iron-containing cofactor heme to cause disease. Heme is
essential to the function of hemoproteins, which are involved in energy generation by the …

All but a few bacterial species have an absolute need for heme, and most are able to
synthesize it via a pathway that is highly conserved among all life domains. Because heme …

Iron is the most abundant transition metal in the human body and its bioavailability is
stringently controlled. In particular, iron is tightly bound to host proteins such as transferrin to …

The use of iron as a cofactor in basic metabolic pathways is essential to both pathogenic
microorganisms and their hosts. It is also a pivotal component of the innate immune …

Preface. Iron is considered to be a minor element employed, in a variety of forms, by nearly
all living organisms. In some cases, it is utilised in large quantities, for instance for the …