Rejuvenation of cells by reprogramming toward the pluripotent state raises increasing
attention. In fact, generation of induced pluripotent stem cells (iPSCs) completely reverses …

ABSTRACT 'Age reprogramming'refers to the process by which the molecular and cellular
pathways of a cell that are subject to age-related decline are rejuvenated without passage …

Induced pluripotent stem cells (IPSCs), with their unlimited regenerative capacity, carry the
promise for tissue replacement to counter age‐related decline. However, attempts to realize …

The discovery of induced pluripotent stem cells (iPSCs) has the potential to revolutionize the
field of regenerative medicine. In the past few years, iPSCs have been the subject of …

Aging is accompanied by the functional decline of cells, tissues, and organs, as well as a
striking increase in a wide range of diseases. The reprogramming of somatic cells to …

The discovery that somatic cells can be induced into a pluripotent state by the expression of
reprogramming factors has enormous potential for therapeutics and human disease …

The ability to reprogram adult somatic cells back to pluripotency presents a powerful tool for
studying cell-fate identity and modeling human disease. However, the reversal of cellular …

Ageing is the gradual decline in organismal fitness that occurs over time leading to tissue
dysfunction and disease. At the cellular level, ageing is associated with reduced function …

Aging is associated with a progressive and functional decline of all tissues and a striking
increase in many “age-related diseases”. Although aging has long been considered an …

Age reprogramming represents a novel method for generating patient-specific tissues for
transplantation. It bypasses the de-differentiation/redifferentiation cycle that is characteristic …