One of the major causes of death in the world is cancer. Due to significant advances in
molecular and cellular biology, previous approaches in cancer treatment have progressed …

Background & Objectives: One of the major causes of death in the world is cancer. Due to
significant advances in molecular and cellular biology, previous approaches in cancer …

Background: Each year, millions of people die from cancer. Radiotherapy is one of the main
treatment strategies for cancer patients. Despite the beneficial roles of treatment with …

The development of new chemotherapeutic agents and concepts of radiation therapy has
led to new perspectives in cancer therapy. Recently developed novel agents interfere with …

PURPOSE: To evaluate the potential radiosensitizing effect of the specific COX-2 inhibitor
celecoxib (Celebrex®) on prostate carcinoma cells in vitro. MATERIALS AND METHODS …

Abstract The selective cyclooxygenase (COX)-2 inhibitor, celecoxib, alone and in
combination with radiation was investigated in vitro and in vivo. Murine mammary tumor line …

Highlights•COX-2 is overexpressed in tumour cells and is involved in cell proliferation and
progression and angiogenesis.•COX-2 inhibitors can block various signalling pathways …

PURPOSE: To investigate the modulation of radiosensitivity by celecoxib, a selective
cyclooxygenase-2 (COX-2) inhibitor, on cancer cells over-and under-expressing COX-2 …

Cyclooxygenase-2 (COX-2) is an enzyme expressed primarily in pathologic states, such as
inflammatory disorders and cancer, where it mediates prostaglandin production. Its …

Cyclooxygenase-2 (COX-2) is an enzyme induced by a variety of factors including tumor
promoters, cytokines, growth factors and hypoxia. It is involved in the metabolic conversion …