Role of JAK-STAT and PPAR-gamma signalling modulators in the prevention of autism and neurological dysfunctions

R Khera, S Mehan, S Kumar, P Sethi, S Bhalla… - Molecular …, 2022 - Springer
The Janus-kinase (JAK) and signal transducer activator of transcription (STAT) signalling
pathways regulate gene expression and control various factors involved in normal …

Therapeutic modulation of JAK-STAT, mTOR, and PPAR-γ signaling in neurological dysfunctions

S Kumar, S Mehan, AS Narula - Journal of Molecular Medicine, 2023 - Springer
The cytokine-activated Janus kinase (JAK)–signal transducer and activator of transcription
(STAT) cascade is a pleiotropic pathway that involves receptor subunit multimerization. The …

Connection between JAK/STAT and PPARγ signaling during the progression of multiple sclerosis: Insights into the modulation of T-cells and immune responses in the …

N Kumar, N Sharma, S Mehan - Current molecular …, 2021 - ingentaconnect.com
Multiple Sclerosis (MS) is a severe brain and spinal cord condition with a diverse
autoimmune response and a wide variety of demyelination symptoms that primarily affect …

Resveratrol attenuates pro-inflammatory cytokines and activation of JAK1-STAT3 in BTBR T+ Itpr3tf/J autistic mice

SF Ahmad, MA Ansari, A Nadeem, SA Bakheet… - European journal of …, 2018 - Elsevier
Autism is a neurodevelopmental disorder characterized by qualitative impairment in
communication, social interaction, and repetitive stereotypic behavior. Resveratrol plays a …

Novel role of peroxisome proliferator activated receptor-α in valproic acid rat model of autism: Mechanistic study of risperidone and metformin monotherapy versus …

EM Elnahas, SA Abuelezz, MI Mohamad… - Progress in Neuro …, 2022 - Elsevier
Autism spectrum disorder (ASD) is a neurodevelopmental disorder of heterogenous etiology
exhibiting a challenge in understanding its exact neuro-pathophysiology. Recently …

PPARγ agonists: potential treatment for autism spectrum disorder by inhibiting the canonical WNT/β-catenin pathway

A Vallée, JN Vallée, Y Lecarpentier - Molecular psychiatry, 2019 - nature.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is characterized by a
deficit in social interactions and communication with repetitive and restrictive behavior. No …

The PPARδ agonist GW0742 restores neuroimmune function by regulating Tim-3 and Th17/Treg-related signaling in the BTBR autistic mouse model

SF Ahmad, A Nadeem, MA Ansari, SA Bakheet… - Neurochemistry …, 2018 - Elsevier
Autism spectrum disorders (ASD) are neurodevelopmental disorders that are characterized
by repetitive behaviors, and impairments in communication and social interaction. Studies …

Targeting PI3K-AKT/mTOR signaling in the prevention of autism

A Sharma, S Mehan - Neurochemistry international, 2021 - Elsevier
Abstract PI3K-AKT/mTOR signaling pathway represents an essential signaling mechanism
for mammalian enzyme-related receptors in transducing signals or biological processes …

Guggulsterone mediated JAK/STAT and PPAR-gamma modulation prevents neurobehavioral and neurochemical abnormalities in propionic acid-induced …

R Khera, S Mehan, S Bhalla, S Kumar, A Alshammari… - Molecules, 2022 - mdpi.com
Autism spectrum disorder is a neurodevelopmental disorder marked by repetitive behaviour,
challenges in verbal and non-verbal communication, poor socio-emotional health, and …

A selective peroxisome proliferator-activated receptor-γ agonist benefited propionic acid induced autism-like behavioral phenotypes in rats by attenuation of …

R Mirza, B Sharma - Chemico-biological interactions, 2019 - Elsevier
Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder in children. It is
diagnosed by two main behavioral phenotypes ie social-communication impairments and …