Role of JAK-STAT and PPAR-gamma signalling modulators in the prevention of autism and neurological dysfunctions
The Janus-kinase (JAK) and signal transducer activator of transcription (STAT) signalling
pathways regulate gene expression and control various factors involved in normal …
pathways regulate gene expression and control various factors involved in normal …
Therapeutic modulation of JAK-STAT, mTOR, and PPAR-γ signaling in neurological dysfunctions
The cytokine-activated Janus kinase (JAK)–signal transducer and activator of transcription
(STAT) cascade is a pleiotropic pathway that involves receptor subunit multimerization. The …
(STAT) cascade is a pleiotropic pathway that involves receptor subunit multimerization. The …
Connection between JAK/STAT and PPARγ signaling during the progression of multiple sclerosis: Insights into the modulation of T-cells and immune responses in the …
Multiple Sclerosis (MS) is a severe brain and spinal cord condition with a diverse
autoimmune response and a wide variety of demyelination symptoms that primarily affect …
autoimmune response and a wide variety of demyelination symptoms that primarily affect …
Resveratrol attenuates pro-inflammatory cytokines and activation of JAK1-STAT3 in BTBR T+ Itpr3tf/J autistic mice
Autism is a neurodevelopmental disorder characterized by qualitative impairment in
communication, social interaction, and repetitive stereotypic behavior. Resveratrol plays a …
communication, social interaction, and repetitive stereotypic behavior. Resveratrol plays a …
Novel role of peroxisome proliferator activated receptor-α in valproic acid rat model of autism: Mechanistic study of risperidone and metformin monotherapy versus …
Autism spectrum disorder (ASD) is a neurodevelopmental disorder of heterogenous etiology
exhibiting a challenge in understanding its exact neuro-pathophysiology. Recently …
exhibiting a challenge in understanding its exact neuro-pathophysiology. Recently …
PPARγ agonists: potential treatment for autism spectrum disorder by inhibiting the canonical WNT/β-catenin pathway
A Vallée, JN Vallée, Y Lecarpentier - Molecular psychiatry, 2019 - nature.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is characterized by a
deficit in social interactions and communication with repetitive and restrictive behavior. No …
deficit in social interactions and communication with repetitive and restrictive behavior. No …
The PPARδ agonist GW0742 restores neuroimmune function by regulating Tim-3 and Th17/Treg-related signaling in the BTBR autistic mouse model
Autism spectrum disorders (ASD) are neurodevelopmental disorders that are characterized
by repetitive behaviors, and impairments in communication and social interaction. Studies …
by repetitive behaviors, and impairments in communication and social interaction. Studies …
Targeting PI3K-AKT/mTOR signaling in the prevention of autism
A Sharma, S Mehan - Neurochemistry international, 2021 - Elsevier
Abstract PI3K-AKT/mTOR signaling pathway represents an essential signaling mechanism
for mammalian enzyme-related receptors in transducing signals or biological processes …
for mammalian enzyme-related receptors in transducing signals or biological processes …
Guggulsterone mediated JAK/STAT and PPAR-gamma modulation prevents neurobehavioral and neurochemical abnormalities in propionic acid-induced …
Autism spectrum disorder is a neurodevelopmental disorder marked by repetitive behaviour,
challenges in verbal and non-verbal communication, poor socio-emotional health, and …
challenges in verbal and non-verbal communication, poor socio-emotional health, and …
A selective peroxisome proliferator-activated receptor-γ agonist benefited propionic acid induced autism-like behavioral phenotypes in rats by attenuation of …
Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder in children. It is
diagnosed by two main behavioral phenotypes ie social-communication impairments and …
diagnosed by two main behavioral phenotypes ie social-communication impairments and …
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