In recent years considerable progress has been made in identifying the impact of mRNA
translation in tumour progression. Cancer cells hijack the pre-existing translation machinery …

The evidence for the importance of aberrant translation in cancer cells is overwhelming.
Reflecting the wealth of data, there are excellent reviews delineating how ribosomes and …

As a convergent mechanism downstream of most oncogenic signals, control of mRNA
translation has emerged as a key driver in establishing and tuning gene expression at …

Tumor cells are continually subjected to diverse stress conditions of the tumor
microenvironment, including hypoxia, nutrient deprivation, and oxidative or genotoxic stress …

Translational control of mRNAs during gene expression allows cells to promptly and
dynamically adapt to a variety of stimuli, including in neoplasia in response to aberrant …

Deregulation of the mRNA translational process has been observed during tumorigenesis.
However, recent findings have shown that deregulation of translation also contributes …

Altered mRNA translational control is emerging as a critical factor in cancer development
and progression. Targeting specific elements of the translational machinery, such as …

Cellular stress is an intrinsic part of cell physiology that underlines cell survival or death. The
ability of mammalian cells to regulate global protein synthesis (aka translational control) …

The past several years have seen dramatic leaps in our understanding of how gene
expression is rewired at the translation level during tumorigenesis to support the …

During their quest for growth, adaptation, and survival, cancer cells create a favorable
environment through the manipulation of normal cellular mechanisms. They increase …