Role of JAK/STAT in interstitial lung diseases; molecular and cellular mechanisms
P Montero, J Milara, I Roger, J Cortijo - International journal of molecular …, 2021 - mdpi.com
Interstitial lung diseases (ILDs) comprise different fibrotic lung disorders characterized by
cellular proliferation, interstitial inflammation, and fibrosis. The JAK/STAT molecular pathway …
cellular proliferation, interstitial inflammation, and fibrosis. The JAK/STAT molecular pathway …
The JAK2 pathway is activated in idiopathic pulmonary fibrosis
J Milara, G Hernandez, B Ballester, A Morell, I Roger… - Respiratory …, 2018 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is the most rapidly progressive and fatal
fibrotic disorder, with no curative therapies. The signal transducer and activator of …
fibrotic disorder, with no curative therapies. The signal transducer and activator of …
The role of JAK/STAT molecular pathway in vascular remodeling associated with pulmonary hypertension
I Roger, J Milara, P Montero, J Cortijo - International journal of molecular …, 2021 - mdpi.com
Pulmonary hypertension is defined as a group of diseases characterized by a progressive
increase in pulmonary vascular resistance (PVR), which leads to right ventricular failure and …
increase in pulmonary vascular resistance (PVR), which leads to right ventricular failure and …
The role of JAK/STAT pathway in fibrotic diseases: molecular and cellular mechanisms
J Liu, F Wang, F Luo - Biomolecules, 2023 - mdpi.com
There are four members of the JAK family and seven of the STAT family in mammals. The
JAK/STAT molecular pathway could be activated by broad hormones, cytokines, growth …
JAK/STAT molecular pathway could be activated by broad hormones, cytokines, growth …
JAK–STAT pathway activation in COPD
L Yew-Booth, MA Birrell, MS Lau… - European …, 2015 - Eur Respiratory Soc
Chronic obstructive pulmonary disease (COPD) is an inflammatory disease of the lung, most
commonly resulting from cigarette smoke exposure, characterised by a largely irreversible …
commonly resulting from cigarette smoke exposure, characterised by a largely irreversible …
Canonical and noncanonical regulatory roles for JAK2 in the pathogenesis of rheumatoid arthritis‐associated interstitial lung disease and idiopathic pulmonary …
S Wang, M Liu, X Li, J Zhang, F Wang… - The FASEB …, 2022 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) and rheumatoid arthritis‐associated interstitial lung
disease (RA‐ILD) are two fibrotic interstitial lung diseases that share the usual interstitial …
disease (RA‐ILD) are two fibrotic interstitial lung diseases that share the usual interstitial …
The role of JAK/STAT signaling pathway and its inhibitors in diseases
P Xin, X Xu, C Deng, S Liu, Y Wang, X Zhou… - International …, 2020 - Elsevier
The JAK/STAT signaling pathway is an universally expressed intracellular signal
transduction pathway and involved in many crucial biological processes, including cell …
transduction pathway and involved in many crucial biological processes, including cell …
JAK/STAT pathway: Extracellular signals, diseases, immunity, and therapeutic regimens
Q Hu, Q Bian, D Rong, L Wang, J Song… - … in Bioengineering and …, 2023 - frontiersin.org
Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were
originally thought to be intracellular signaling pathways that mediate cytokine signals in …
originally thought to be intracellular signaling pathways that mediate cytokine signals in …
JAK/STAT signal transduction: promising attractive targets for immune, inflammatory and hematopoietic diseases
Q Gao, X Liang, AS Shaikh, J Zang, W Xu… - Current Drug …, 2018 - ingentaconnect.com
Background: JAK/STAT signal pathway, a requisite part in the signaling process of growth
factors and cytokines, has become attractive targets for numerous immune, inflammatory …
factors and cytokines, has become attractive targets for numerous immune, inflammatory …
JAK2 mediates lung fibrosis, pulmonary vascular remodelling and hypertension in idiopathic pulmonary fibrosis: an experimental study
J Milara, B Ballester, A Morell, JL Ortiz, J Escrivá… - Thorax, 2018 - thorax.bmj.com
Background Pulmonary hypertension (PH) is a common disorder in patients with idiopathic
pulmonary fibrosis (IPF) and portends a poor prognosis. Recent studies using vasodilators …
pulmonary fibrosis (IPF) and portends a poor prognosis. Recent studies using vasodilators …