A systematic approach to design and prepare solid dispersions of poorly water-soluble drug

S Verma, VS Rudraraju - AAPS PharmSciTech, 2014 - Springer
The objective of the present study was to define a systematic approach to design and
prepare solid dispersions of poorly water-soluble drug. The systematic approach can be …

Investigation of phase diagrams and physical stability of drug–polymer solid dispersions

J Lu, S Shah, S Jo, S Majumdar, A Gryczke… - Pharmaceutical …, 2015 - Taylor & Francis
Solid dispersion technology has been widely explored to improve the solubility and
bioavailability of poorly water-soluble compounds. One of the critical drawbacks associated …

Theoretical prediction of a phase diagram for solid dispersions

B Tian, X Wang, Y Zhang, K Zhang, Y Zhang… - Pharmaceutical …, 2015 - Springer
Purpose To predict the temperature-composition phase diagram of solid dispersions (SDs)
through theoretical approaches using cinnarizine-Soluplus® SD as a model system and …

[PDF][PDF] Solid dispersion: A promising technique to enhance solubility of poorly water soluble drug

A Sharma, CP Jain - International Journal of Drug Delivery, 2011 - Citeseer
Poorly water soluble compounds have solubility and dissolution related bioavailability
problems. The present review deals in detail about solid dispersion technology and its …

Solubility parameter-based screening methods for early-stage formulation development of itraconazole amorphous solid dispersions

P Piccinni, Y Tian, A McNaughton… - Journal of Pharmacy …, 2016 - academic.oup.com
Objectives This article uses conventional and newly extended solubility parameter (δ)
methods to identify polymeric materials capable of forming amorphous dispersions with …

[PDF][PDF] Solid dispersions: Solubility enhancement technique for poorly soluble drugs

SM Wairkar, RS Gaud - International Journal of Research in …, 2013 - researchgate.net
Last three decades of drug discovery are governed by combinatorial chemistry and high
throughput screening. As of result, more than 40% newly discovered drug candidates are …

Classification of solid dispersions: correlation to (i) stability and solubility (ii) preparation and characterization techniques

F Meng, U Gala, H Chauhan - Drug development and industrial …, 2015 - Taylor & Francis
Solid dispersion has been a topic of interest in recent years for its potential in improving oral
bioavailability, especially for poorly water soluble drugs where dissolution could be the rate …

[PDF][PDF] Solid dispersions: an approach to enhance solubility of poorly water soluble drug

I Sridhar, A Doshi, B Joshi, V Wankhede, J Doshi - J Sci Innov Res, 2013 - jsirjournal.com
Solid dispersions have attracted considerable interest as an efficient means of improving the
dissolution rate and hence the bioavailability of a range of poorly water-soluble drugs. Solid …

Using Flory–Huggins phase diagrams as a pre-formulation tool for the production of amorphous solid dispersions: a comparison between hot-melt extrusion and spray …

Y Tian, V Caron, DS Jones, AM Healy… - Journal of Pharmacy …, 2014 - academic.oup.com
Objectives Amorphous drug forms provide a useful method of enhancing the dissolution
performance of poorly water-soluble drugs; however, they are inherently unstable. In this …

A review: Increasing solubility of poorly soluble drugs, by solid dispersion technique

NS Pradeep - Research Journal of Pharmacy and Technology, 2011 - indianjournals.com
The solubility of a drug is one of the most important part of the drug formulation
development. The effectiveness of drug is completely depends on the, solubility and …