Background Cyclooxygenase (COX) is the rate-limiting enzyme that catalyzes the formation
of prostaglandins. The inducible isoform of COX (COX-2) is highly expressed in aggressive …

Background: Cyclooxygenase-2 (COX-2) overexpression clearly plays an important role in
the pathogenesis of breast cancer. In this study, we analysed the relationship between COX …

Abstract Cyclooxygenase (COX)—2, an inducible isoform of cyclooxygenases, regulates the
rapid production of high levels of prostaglandins during inflammation. Cyclooxygenase-2 is …

Cohesive scientific evidence from molecular, animal, and human investigations supports the
hypothesis that constitutive overexpression of cyclooxygenase-2 (COX-2) is a ubiquitous …

Abstract Cyclooxygenase-2 (COX-2) is associated with poor-prognosis breast cancer. We
used a nude mouse xenograft model to determine the effects of COX-2 inhibition in breast …

Cyclooxygenases (COX) are rate-limiting enzymes involved in the conversion of PLA2-
mobilized arachidonic acid into prostaglandins and thromboxanes. COX-2 is a key mediator …

Abstract Cyclooxygenase-2 (COX-2), the enzyme that converts arachidonic acid to
prostaglandin H 2, is expressed in normal brain and kidney, activated macrophages …

BACKGROUND Cyclooxygenases regulate the production of prostaglandins and play a role
in tumor development and progression. The authors investigated the prognostic impact of …

Abstract Cyclooxygenase-2 (COX-2) inhibitors are rapidly emerging as a new generation of
therapeutic drug in combination with chemotherapy or radiation therapy for the treatment of …

Aims: Cyclo-oxygenases 1 and 2 (COX-1 and COX-2) are key enzymes in prostaglandin
biosynthesis. COX-2 is induced by a wide variety of stimuli, and present during inflammation …