Inhibition of PI3K-AKT Signaling Blocks PGE2-Induced COX-2 Expression in Lung Adenocarcinoma
J Yang, X Wang, Y Gao, C Fang, F Ye… - OncoTargets and …, 2020 - Taylor & Francis
Purpose Cyclooxygenase-2 (COX-2) and its enzymatic product prostaglandin E2 (PGE2)
possess tumor-promoting activity, and COX-2 is considered as a candidate for targeted …
possess tumor-promoting activity, and COX-2 is considered as a candidate for targeted …
Ciglitazone mediates COX-2 dependent suppression of PGE2 in human non-small cell lung cancer cells
S Hazra, SM Dubinett - Prostaglandins, leukotrienes and essential fatty …, 2007 - Elsevier
Background: Cyclooxygenase-2 (COX-2) over-expression and subsequent prostaglandin E2
(PGE2) production are frequently associated with human non-small-cell lung cancer …
(PGE2) production are frequently associated with human non-small-cell lung cancer …
COX‐2 in lung cancer: Mechanisms, development, and targeted therapies
X Liu, J Zhang, W Sun, J Cao… - Chronic Diseases and …, 2024 - Wiley Online Library
Lung cancer (LC) is the leading cause of cancer‐related death worldwide, with non‐small
cell lung cancer (NSCLC) comprising 85% of all cases. COX‐2, an enzyme induced …
cell lung cancer (NSCLC) comprising 85% of all cases. COX‐2, an enzyme induced …
Prostaglandin E2 Activates Mitogen-Activated Protein Kinase/Erk Pathway Signaling and Cell Proliferation in Non–Small Cell Lung Cancer Cells in an Epidermal …
K Krysan, KL Reckamp, H Dalwadi, S Sharma… - Cancer research, 2005 - AACR
Abstract Cyclooxygenase 2 (COX-2) overexpression is found in a wide variety of human
cancers and is linked to all stages of tumorigenesis. Elevated tumor COX-2 expression is …
cancers and is linked to all stages of tumorigenesis. Elevated tumor COX-2 expression is …
IL-4 regulates COX-2 and PGE2 production in human non-small cell lung cancer
X Cui, SC Yang, S Sharma, N Heuze-Vourc'h… - Biochemical and …, 2006 - Elsevier
IL-4 is a type 2 cytokine that may mediate pleiotropic effects in the NSCLC
microenvironment. Here, we investigated whether IL-4 regulates PGE2 production in …
microenvironment. Here, we investigated whether IL-4 regulates PGE2 production in …
Prostaglandin E2 Promotes Lung Cancer Cell Migration via EP4-βArrestin1-c-Src Signalsome
JI Kim, V Lakshmikanthan, N Frilot, Y Daaka - Molecular Cancer Research, 2010 - AACR
Many human cancers express elevated levels of cyclooxygenase-2 (COX-2), an enzyme
responsible for the biosynthesis of prostaglandins. Available clinical data establish the …
responsible for the biosynthesis of prostaglandins. Available clinical data establish the …
Cyclooxygenase-2 is associated with malignant phenotypes in human lung cancer
W Li, W Yue, H Wang, B Lai, X Yang… - Oncology …, 2016 - spandidos-publications.com
The objective of the present study was to investigate whether cyclooxygenase-2 (COX-2) is
associated with malignancy, and to investigate its molecular mechanisms in human lung …
associated with malignancy, and to investigate its molecular mechanisms in human lung …
Co-expression of Cox-2 and EGFR in stage I human bronchial adenocarcinomas
K Araki, K Hashimoto, TD Ardyanto, M Osaki… - Lung Cancer, 2004 - Elsevier
Cyclooxygenase (Cox)-2 plays an important role in cell proliferation, carcinogenesis and
tumor growth, in part through the synthesis of prostaglandin E2 (PGE2) as well as through …
tumor growth, in part through the synthesis of prostaglandin E2 (PGE2) as well as through …
Effects of COX-2 inhibition on expression of vascular endothelial growth factor and interleukin-8 in lung cancer cells
YM Zhu, NSM Azahri, DCW Yu, PJ Woll - BMC cancer, 2008 - Springer
Abstract Background Cyclooxygenase (COX)-2 has been implicated in tumour progression,
angiogenesis and metastasis in non-small cell lung cancer (NSCLC). We speculated that …
angiogenesis and metastasis in non-small cell lung cancer (NSCLC). We speculated that …
COX-2 inhibitors suppress lung cancer cell growth by inducing p21 via COX-2 independent signals
SW Han, J Roman - Lung Cancer, 2006 - Elsevier
COX-2 has been implicated in the control of human non-small cell lung carcinoma (NSCLC)
cell growth. The mechanisms by which COX-2 exerts its mitogenic effects have not been …
cell growth. The mechanisms by which COX-2 exerts its mitogenic effects have not been …