Heritability analysis of cytokines as intermediate phenotypes of tuberculosis
CM Stein, D Guwatudde, M Nakakeeto… - The Journal of …, 2003 - academic.oup.com
Numerous studies have provided support for genetic susceptibility to tuberculosis (TB);
however, heterogeneity in disease expression has hampered previous genetic studies. The …
however, heterogeneity in disease expression has hampered previous genetic studies. The …
Linkage and association analysis of candidate genes for TB and TNFα cytokine expression: evidence for association with IFNGR1, IL-10, and TNF receptor 1 genes
CM Stein, S Zalwango, AB Chiunda, C Millard… - Human genetics, 2007 - Springer
Tuberculosis (TB) is a growing public health threat globally and several studies suggest a
role of host genetic susceptibility in increased TB risk. As part of a household contact study …
role of host genetic susceptibility in increased TB risk. As part of a household contact study …
Evidence for a major gene influence on tumor necrosis factor-α expression in tuberculosis: path and segregation analysis
CM Stein, L Nshuti, AB Chiunda, WH Boom… - Human …, 2005 - karger.com
Objective: Tuberculosis (TB) is a growing global public health problem. Several studies
suggest a role for host genetics in disease susceptibility, but studies to date have been …
suggest a role for host genetics in disease susceptibility, but studies to date have been …
Differential serum cytokine levels are associated with cytokine gene polymorphisms in north Indians with active pulmonary tuberculosis
Abstract Globally only 5–10% of people encountering Mycobacterium tuberculosis have a
lifetime risk of active disease indicating a strong host genetic bias towards development of …
lifetime risk of active disease indicating a strong host genetic bias towards development of …
Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study
M Möller, A Nebel, PD Van Helden, S Schreiber… - BMC infectious …, 2010 - Springer
Background Interferon gamma is a major macrophage-activating cytokine during infection
with Mycobacterium tuberculosis, the causative pathogen of tuberculosis, and its role has …
with Mycobacterium tuberculosis, the causative pathogen of tuberculosis, and its role has …
High heritability of antimycobacterial immunity in an area of hyperendemicity for tuberculosis disease
Human antimycobacterial immunity is a critical component of tuberculosis (TB) pathogenesis
that is often used to infer the presence of TB infection. We report high heritability (> 50%) for …
that is often used to infer the presence of TB infection. We report high heritability (> 50%) for …
Cytokine gene polymorphisms are associated with susceptibility to tuberculosis in an Amerindian population
JD Lindenau, LSP Guimarães… - … of tuberculosis and …, 2014 - ingentaconnect.com
SETTING: Cytokines play an important role in anti-tuberculosis immune response, combined
with antigen-presenting cells and lymphocytes. Immune response gene polymorphisms …
with antigen-presenting cells and lymphocytes. Immune response gene polymorphisms …
Assessment of the interleukin 1 gene cluster and other candidate gene polymorphisms in host susceptibility to tuberculosis
R Bellamy, C Ruwende, T Corrah, K McAdam… - Tubercle and Lung …, 1998 - Elsevier
Setting: A study of tuberculosis cases and healthy blood donor controls from the Western
Region of The Gambia, West Africa. Objective: To investigate the potential role of candidate …
Region of The Gambia, West Africa. Objective: To investigate the potential role of candidate …
Identification of a Major Locus, TNF1, That Controls BCG-Triggered Tumor Necrosis Factor Production by Leukocytes in an Area Hyperendemic for Tuberculosis
Background. Tumor necrosis factor (TNF) is a key immune regulator of tuberculosis
resistance, as exemplified by the highly increased risk of tuberculosis disease among …
resistance, as exemplified by the highly increased risk of tuberculosis disease among …
Footprints of genetic susceptibility to pulmonary tuberculosis: cytokine gene variants in north Indians
M Bose, P Jha… - Indian Journal of …, 2012 - journals.lww.com
Methods: Pulmonary TB (n= 110) patients and 215 healthy controls (HC) from north India
were genotyped. Purified multiplex PCR products were subjected to mass spectrometry …
were genotyped. Purified multiplex PCR products were subjected to mass spectrometry …