Unconjugated bilirubin (UCB) is known to be one of the most potent endogenous antioxidant
substances. While hyperbilirubinemia has long been recognized as an ominous sign of liver …

Bilirubin has several physiological functions, both beneficial and harmful. In addition to
reactive oxygen species-scavenging activities, bilirubin has potent immunosuppressive …

For long time bilirubin was only considered as a potentially dangerous sign of liver diseases,
but it now appears clear that it is also a powerful signaling molecule. Together with potent …

Unconjugated bilirubin (UCB), the principal mammalian bile pigment, is the end product of
heme catabolism. Both belong to the superfamily of tetrapyrrolic compounds that serve …

Recent research on bilirubin, a historically well-known waste product of heme catabolism,
suggests an entirely new function as a metabolic hormone that drives gene transcription by …

Nearly a century ago, jaundiced patients were observed to have surprising and
spontaneous remissions from incurable immunologic diseases including rheumatoid …

Bilirubin (BR) is the final product of haem catabolism. Disruptions along BR
metabolic/transport pathways resulting from inherited disorders can increase plasma BR …

Bilirubin is a potent antioxidant but can be toxic at high concentrations. This article critically
reviews the reported relationships of plasma bilirubin levels to the severity and/or incidence …

There is strong evidence that serum free bilirubin concentration has significant effects on
morbidity and mortality in the most significant health conditions of our times, including …

Reactive oxygen species (ROS) and signaling events are involved in the pathogenesis of
endothelial dysfunction and represent a major contribution to vascular regulation. Molecular …