Myofibroblasts are contractile, α-smooth muscle actin-positive cells with multiple roles in
pathophysiological processes. Myofibroblasts mediate wound contractions, but their …

Fibrosis: recent advances in myofibroblast biology and new therapeutic perspectives - PMC Back
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It is generally accepted that fibroblast-to-myofibroblast differentiation represents a key event
during wound healing and tissue repair. The high contractile force generated by …

Significance: Myofibroblasts are responsible for wound closure that occurs in healed acute
wounds. However, their actions can result in disfiguring scar contractures, compromised …

The importance of proper skin wound healing becomes evident when our body's repair
mechanisms fail, leading to either non-healing (chronic) wounds or excessive repair …

In 1971, Gabbiani and co-workers discovered and characterized the “modification of
fibroblasts into cells which are capable of an active spasm”(contraction) in rat wound …

Myofibroblasts are characterized by their expression of α-smooth muscle actin, their
enhanced contractility when compared to normal fibroblasts and their increased synthetic …

Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …

Fibroblasts and myofibroblasts play a myriad of important roles in human tissue function,
especially in wound repair and healing. Among all cells, fibroblasts are group of cells that …

The discovery of the myofibroblast has opened new perspectives for the comprehension of
the biological mechanisms involved in wound healing and fibrotic diseases. In recent years …