A major roadblock to successful organ bioengineering is the need for a functional vascular
network within the engineered tissue. Here, we describe the fabrication of three …

At this time, the only definitive treatment of hepatic failure is liver transplantation. However,
transplantation has been limited by the severely limited supply of human donor livers …

Initially hailed as the ultimate solution to organ failure, engineering of vascularized tissues
such as the liver has stalled because of the need for a well-structured circulatory system that …

A major goal of liver tissue engineering is to understand how the constituent cell types
interact to achieve liver-specific structure and function. Here we show that hepatocytes …

The use of synthetic and naturally-derived scaffolds for bioengineering of solid organs has
been limited due to a lack of an integrated vascular network. Here, we describe fabrication of …

Allogeneic liver transplantation is still deemed the gold standard solution for end-stage
organ failure; however, donor organ shortages have led to extended waiting lists for organ …

Over the past two decades, great strides have been made in the field of tissue engineering.
Many of the initial attempts to develop an engineered tissue construct were based on the …

Whole‐organ decellularization has been identified as a promising choice for tissue
engineering. The aim of the present study was to engineer intact whole rat liver scaffolds …

Tissue engineering is one approach to address the donor-organ shortage, but to attain
clinically significant viable cell densities in thick tissues, laboratory-constructed tissues must …

The construction of a functional liver-tissue equivalent using tissue engineering is a very
important goal because the liver is a central organ in the body. However, the construction of …