While genetic changes are critical for the malignant transformation of epithelial cells, the
microenvironment in which the cells reside also governs carcinogenesis. Most tumors arise …

The tumor microenvironment (TME) represents a milieu that enables tumor cells to acquire
the hallmarks of cancer. The TME is heterogeneous in composition and consists of cellular …

Lung cancer is a major global health problem, as it is the leading cause of cancer-related
deaths worldwide. Major advances in the identification of key mutational alterations have led …

• The pulmonary microenvironment represents a unique milieu in which lung carcinogenesis
proceeds in complicity with the four main components of the tumor microenvironment (TME) …

The inflammatory tumor microenvironment (TME) has a multifaceted role in tumor initiation,
progression, and metastasis. Whereas genetic changes are critical for the malignant …

Lung carcinogenesis is a complex process requiring the acquisition of genetic mutations that
confer the malignant phenotype as well as epigenetic alterations that may be manipulated in …

Understanding the host response to lung cancer is critical in the development of long-term
therapeutic responses and cures for advanced-stage disease. While state-of-the-art …

Lung cancer is the leading cause of cancer-related mortality worldwide. In 2022 the Cancer
Statistics Center calculated an estimated four new cases and one death per minute from …

Our understanding of lung cancer biology has rapidly expanded in recent years. Lung
cancer, unlike most human cancers, can be traced to an environmental risk factor in the …

This is the second part of volume Lung Cancer and Personalized Medicine. Part I of this
volume, available as a separate book, discussed lung cancer as a disease, the available …