There has been mounting evidence of a causal role for telomere dysfunction in a number of
degenerative disorders. Their manifestations encompass common disease states such as …

A constellation of related genetic diseases are caused by defects in the telomere
maintenance machinery. These disorders, often referred to as telomeropathies, share …

Telomeres, consisting of nucleotide repeats and a protein complex at chromosome ends,
are essential in maintaining chromosomal integrity. Dyskeratosis congenita (DC) is the …

Telomeres and telomerase were initially discovered in pursuit of questions about how the
ends of chromosomes are maintained. The implications of these discoveries to age-related …

Telomeres are specialized nucleoprotein structures at the ends of linear chromosomes that
prevent the activation of DNA damage response and repair pathways. Numerous factors …

Telomeres are dynamic nucleoprotein-DNA structures that cap and protect linear
chromosome ends. Several monogenic inherited diseases that display features of human …

Recent advances have defined a role for abnormally short telomeres in a broad spectrum of
genetic disorders. They include rare conditions such as dyskeratosis congenita as well …

Telomere length shortens with age and predicts the onset of replicative senescence.
Recently, short telomeres have been linked to the etiology of degenerative diseases such as …

Mutations in genes encoding proteins required for telomere structure, replication, repair and
length maintenance are associated with several debilitating human genetic disorders. These …

Telomere biology was first studied in maize, ciliates, yeast, and mice, and in recent decades,
it has informed understanding of common disease mechanisms with broad implications for …