Stem cells therapeutic effect in a reserpine-induced fibromyalgia rat model: A possible NLRP3 inflammasome modulation with neurogenesis promotion in the cerebral …

SA Mokhemer, MK Desouky, AK Abdelghany… - Life Sciences, 2023 - Elsevier
Fibromyalgia is a chronic pain syndrome with a multifactorial pathophysiology affecting 2–
8% of the population. Aims To investigate the therapeutic effects of bone marrow …

[HTML][HTML] Neuroprotective effects of human umbilical cord mesenchymal stromal cells in PD mice via centrally and peripherally suppressing NLRP3 inflammasome …

L Zhou, X Wang, X Wang, J An, X Zheng, D Han… - Biomedicine & …, 2022 - Elsevier
Mesenchymal stromal cells (MSCs) exhibit beneficial anti-inflammatory effects against
Parkinson's disease (PD) via immunomodulatory actions. However, the underlying …

Evaluation of endothelial dysfunction and autophagy in fibromyalgia-related vascular and cerebral cortical changes and the ameliorative effect of fisetin

FM Ghoneim, SM Abo-Elkhair, AZ Elsamanoudy… - Cells, 2021 - mdpi.com
Fibromyalgia (FM) is a common chronic pain syndrome that affects 1% to 5% of the
population. We aimed to investigate the role of endothelial dysfunction and autophagy in …

Adipose-derived mesenchymal stem cells protect against CMS-induced depression-like behaviors in mice via regulating the Nrf2/HO-1 and TLR4/NF-κB signaling …

X Huang, G Fei, W Liu, J Ding, Y Wang… - Acta Pharmacologica …, 2020 - nature.com
Increasing studies show that inflammatory processes may be involved in depressive
disorders. Nuclear factor erythroid-2 related factor 2 (Nrf2) modulates tissue microglial M1 …

Analysis of the Influence of IL-6 and the Activation of the Jak/Stat3 Pathway in Fibromyalgia

Y Marino, A Arangia, M Cordaro, R Siracusa… - Biomedicines, 2023 - mdpi.com
Background: Fibromyalgia is a medical condition that affects a small percentage of the
population, with no known effective treatment. There is evidence to suggest that …

Exercise reduces pain and deleterious histological effects in fibromyalgia-like model

EG Ferrarini, ECD Gonçalves, JF Menegasso… - Neuroscience, 2021 - Elsevier
Fibromyalgia (FM) is characterized by chronic pain and associated comorbidities such as
fatigue, anxiety, depression, and sleep disorders. There is a large amount of evidence …

The NLRP3 inflammasome is involved in the neuroprotective mechanism of neural stem cells against microglia-mediated toxicity in SH-SY5Y cells via the attenuation …

EWL Chan, S Krishnansamy, C Wong, SY Gan - Neurotoxicology, 2019 - Elsevier
The cognitive impairment caused by Alzheimer's disease (AD) is associated with beta-
amyloid (Aβ) and tau proteins, and is accompanied by inflammation. Recently, a novel …

Human neural stem cell secretome inhibits lipopolysaccharide-induced neuroinflammation through modulating microglia polarization by activating peroxisome …

J Zhou, W Ni, Y Ling, X Lv, D Niu, Y Zeng… - Stem Cells and …, 2022 - liebertpub.com
Neuroinflammation is one of the typical events in multiple neurodegenerative diseases,
whereas microglia are the critical participants in the pathogenesis of neuroinflammation …

Exercise Training Alleviates Symptoms and Cognitive Decline in a Reserpine-induced Fibromyalgia Model by Activating Hippocampal PGC-1α/FNDC5/BDNF …

M Belviranlı, N Okudan, T Sezer - Neuroscience, 2024 - Elsevier
The purpose of this study was to assess, from a behavioral, biochemical, and molecular
standpoint, how exercise training affected fibromyalgia (FM) symptoms in a reserpine …

The protective effect of melatonin on neural stem cell against LPS‐induced inflammation

J Song, SM Kang, KM Lee… - BioMed research …, 2015 - Wiley Online Library
Stem cell therapy for tissue regeneration has several limitations in the fact that transplanted
cells could not survive for a long time. For solving these limitations, many studies have …