JAKs and STATs in immunity, immunodeficiency, and cancer
JAKs and STATs in Immunity, Immunodeficiency, and Cancer | New England Journal of Medicine
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The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus
MH Heim - Journal of Receptors and Signal Transduction, 1999 - Taylor & Francis
The Jak-STAT pathway was originally discovered through the study of interferon induced
intracellular signal transduction. Meanwhile, a large number of cytokines, hormones and …
intracellular signal transduction. Meanwhile, a large number of cytokines, hormones and …
[HTML][HTML] JAKs and STATs from a clinical perspective: loss-of-function mutations, gain-of-function mutations, and their multidimensional consequences
N Ott, L Faletti, M Heeg, V Andreani… - Journal of clinical …, 2023 - Springer
The JAK/STAT signaling pathway plays a key role in cytokine signaling and is involved in
development, immunity, and tumorigenesis for nearly any cell. At first glance, the JAK/STAT …
development, immunity, and tumorigenesis for nearly any cell. At first glance, the JAK/STAT …
[PDF][PDF] SnapShot: Jak-STAT Signaling II
The JAK-STAT pathway is an evolutionarily conserved signal transduction paradigm,
providing mechanisms for rapid receptor-to-nucleus communication and transcription …
providing mechanisms for rapid receptor-to-nucleus communication and transcription …
[HTML][HTML] JAK and STAT signaling molecules in immunoregulation and immune-mediated disease
The discovery of the Janus kinase (JAK)-signal transducer and activator of transcripton
(STAT) signaling pathway, a landmark in cell biology, provided a simple mechanism for …
(STAT) signaling pathway, a landmark in cell biology, provided a simple mechanism for …
JAK: not just another kinase
RP Agashe, SM Lippman, R Kurzrock - Molecular cancer therapeutics, 2022 - AACR
The JAK/STAT axis is implicated in cancer, inflammation, and immunity. Numerous
cytokines/growth factors affect JAK/STAT signaling. JAKs (JAK1, JAK2, JAK3, and TYK 2) …
cytokines/growth factors affect JAK/STAT signaling. JAKs (JAK1, JAK2, JAK3, and TYK 2) …
[HTML][HTML] Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer
C Xue, Q Yao, X Gu, Q Shi, X Yuan, Q Chu… - Signal transduction and …, 2023 - nature.com
The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway
is an evolutionarily conserved mechanism of transmembrane signal transduction that …
is an evolutionarily conserved mechanism of transmembrane signal transduction that …
[HTML][HTML] The JAK/STAT signaling pathway: from bench to clinic
X Hu, J Li, M Fu, X Zhao, W Wang - Signal transduction and targeted …, 2021 - nature.com
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …
Jaks and STATs: biological implications
WJ Leonard, JJ O'Shea - Annual review of immunology, 1998 - annualreviews.org
▪ Abstract Cytokines and interferons are molecules that play central roles in the regulation of
a wide array of cellular functions in the lympho-hematopoietic system. These factors …
a wide array of cellular functions in the lympho-hematopoietic system. These factors …
Regulation of JAK–STAT signalling in the immune system
K Shuai, B Liu - Nature Reviews Immunology, 2003 - nature.com
The cytokine-activated Janus kinase (JAK)–signal transducer and activator of transcription
(STAT) pathway has an important role in the control of immune responses. Dysregulation of …
(STAT) pathway has an important role in the control of immune responses. Dysregulation of …