Chronic kidney disease (CKD) is a severe clinical syndrome with significant socioeconomic
impact worldwide. Orderly energy metabolism is essential for normal kidney function and …

The pathophysiology of chronic kidney disease (CKD) is driven by alterations in surviving
nephrons to sustain renal function with ongoing nephron loss. Oxygen supply-demand …

The metabolic syndrome is defined by the concurrent presence of at least three metabolic
disorders that are associated with an increased risk of cardiovascular disease and diabetes …

Impaired kidney function and chronic kidney disease (CKD) leading to kidney failure and
end-stage renal disease (ESRD) is a serious medical condition associated with increased …

Background: The kidney requires abundant blood supply, and oxygen is transmitted by
diffusion through blood vessels. Most physiological metabolism of the kidney depends on …

Background CKD is a significant contributor to morbidity and mortality. A better
understanding of mechanisms underlying CKD progression is indispensable for developing …

The 2 most common causes of chronic kidney disease worldwide (type 2 diabetes and
obesity) are states of nutrient excess, suggesting that fuel overabundance leads to …

Metabolic syndrome and its components are associated with chronic kidney disease (CKD)
development. Insulin resistance (IR) plays a central role in the metabolic syndrome and is …

Chronic kidney disease (CKD) has been recognized as a leading public health problem
worldwide. Through its effect on cardiovascular risk and end-stage kidney disease, CKD …

Kidney tubules have high metabolic activity to support solute transport and other cellular
functions. Energy generation in the kidney is largely dependent on mitochondrial oxidative …