Heat-labile enterotoxin-induced PERK-CHOP pathway activation causes intestinal epithelial cell apoptosis

X Lu, C Li, C Li, P Li, E Fu, Y Xie, F Jin - Frontiers in Cellular and …, 2017 - frontiersin.org
Enterotoxigenic Escherichia coli (ETEC) is a leading cause of diarrhea among children and
travelers in developing countries, and heat-labile enterotoxin (LT) is one of the most …

Heat‐labile enterotoxin‐induced activation of NF‐κB and MAPK pathways in intestinal epithelial cells impacts enterotoxigenic Escherichia coli (ETEC) adherence

X Wang, X Gao, PR Hardwidge - Cellular microbiology, 2012 - Wiley Online Library
Enterotoxigenic Escherichia coli (ETEC) causes human morbidity and mortality in
developing nations and is an emerging threat to food safety in developed nations. The ETEC …

Heat stress induced IPEC‐J2 cells barrier dysfunction through endoplasmic reticulum stress mediated apoptosis by p‐eif2α/CHOP pathway

Y Cui, L Chen, X Zhou, Z Tang… - Journal of cellular …, 2022 - Wiley Online Library
Heat stress (HS) induced by high ambient temperatures compromises intestinal epithelial
cell. However, the underlying mechanisms by which HS causes intestinal barrier dysfunction …

GABA attenuates ETEC-induced intestinal epithelial cell apoptosis involving GABA AR signaling and the AMPK-autophagy pathway

Y Xia, S Chen, Y Zhao, S Chen, R Huang, G Zhu… - Food & function, 2019 - pubs.rsc.org
Enterotoxigenic Escherichia coli (ETEC) triggers diarrhea in humans and livestock. We have
previously showed that ETEC promotes intestinal epithelial cell apoptosis and increases …

Heat-Stable Enterotoxins of Enterotoxigenic Escherichia coli and Their Impact on Host Immunity

H Wang, Z Zhong, Y Luo, E Cox, B Devriendt - Toxins, 2019 - mdpi.com
Enterotoxigenic Escherichia coli (ETEC) are an important diarrhea-causing pathogen and
are regarded as a global threat for humans and farm animals. ETEC possess several …

Enterotoxigenic Escherichia coli infection promotes apoptosis in piglets

Y Xia, P Bin, S Liu, S Chen, J Yin, G Liu, Z Tang… - Microbial …, 2018 - Elsevier
Enterotoxigenic Escherichia coli (ETEC), as a universal pathogen, often causes diarrhea in
animals and humans. However, whether ETEC infection induces apoptosis in host remains …

Enterotoxigenic Escherichia coli heat-labile toxin drives enteropathic changes in small intestinal epithelia

A Sheikh, B Tumala, TJ Vickers, JC Martin… - Nature …, 2022 - nature.com
Enterotoxigenic E. coli (ETEC) produce heat-labile (LT) and/or heat-stable (ST) enterotoxins,
and commonly cause diarrhea in resource-poor regions. ETEC have been linked repeatedly …

Enterotoxigenic Escherichia coli Flagellin Inhibits TNF-Induced NF-κB Activation in Intestinal Epithelial Cells

G Wang, BV Geisbrecht, C Rueter, PR Hardwidge - Pathogens, 2017 - mdpi.com
Enterotoxigenic Escherichia coli (ETEC) causes childhood diarrhea in developing countries.
ETEC strains produce the heat-labile enterotoxin (LT) and/or heat-stable enterotoxins (ST) …

Heat-labile enterotoxin enhances F4-producing enterotoxigenic E. coli adhesion to porcine intestinal epithelial cells by upregulating bacterial adhesins and STb …

Q Duan, S Pang, L Feng, J Liu, L Lv, B Li, Y Liang… - Veterinary …, 2022 - Springer
As one of the crucial enterotoxins secreted by enterotoxigenic Escherichia coli (ETEC), heat-
labile enterotoxin (LT) enhances bacterial adherence both in vivo and in vitro; however, the …

Heat-Labile Enterotoxin Decreases Macrophage Phagocytosis of Enterotoxigenic Escherichia coli

IE Hollifield, NI Motyka, KA Fernando, JP Bitoun - Microorganisms, 2023 - mdpi.com
Enterotoxigenic E. coli (ETEC) are endemic in low-resource settings and cause robust
secretory diarrheal disease in children less than five years of age. ETEC cause secretory …