[HTML][HTML] An IDH1-vitamin C crosstalk drives human erythroid development by inhibiting pro-oxidant mitochondrial metabolism
P Gonzalez-Menendez, M Romano, H Yan… - Cell reports, 2021 - cell.com
The metabolic changes controlling the stepwise differentiation of hematopoietic stem and
progenitor cells (HSPCs) to mature erythrocytes are poorly understood. Here, we show that …
progenitor cells (HSPCs) to mature erythrocytes are poorly understood. Here, we show that …
IDH1 mutation contributes to myeloid dysplasia in mice by disturbing heme biosynthesis and erythropoiesis
Y Gu, R Yang, Y Yang, Y Zhao… - Blood, The Journal …, 2021 - ashpublications.org
Isocitrate dehydrogenase (IDH) mutations are common genetic alterations in myeloid
disorders, including acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) …
disorders, including acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) …
Isocitrate dehydrogenase 3b is required for spermiogenesis but dispensable for retinal viability
Isocitrate dehydrogenase 3 (IDH3) is a key enzyme in the mitochondrial tricarboxylic acid
(TCA) cycle, which catalyzes the decarboxylation of isocitrate into α-ketoglutarate and …
(TCA) cycle, which catalyzes the decarboxylation of isocitrate into α-ketoglutarate and …
Erythroid differentiation displays a peak of energy consumption concomitant with glycolytic metabolism rearrangements
A Richard, E Vallin, C Romestaing, D Roussel… - PLoS …, 2019 - journals.plos.org
Our previous single-cell based gene expression analysis pointed out significant variations of
LDHA level during erythroid differentiation. Deeper investigations highlighted that a …
LDHA level during erythroid differentiation. Deeper investigations highlighted that a …
IDH1-Mutant Preleukemic Hematopoietic Stem Cells Can Be Eliminated by Inhibition of Oxidative Phosphorylation
Rare preleukemic hematopoietic stem cells (pHSC) harboring only the initiating mutations
can be detected at the time of acute myeloid leukemia (AML) diagnosis. pHSCs are the …
can be detected at the time of acute myeloid leukemia (AML) diagnosis. pHSCs are the …
Autophagy regulated by the HIF/REDD1/mTORC1 signaling is progressively increased during erythroid differentiation under hypoxia
J Li, C Quan, YL He, Y Cao, Y Chen… - Frontiers in Cell and …, 2022 - frontiersin.org
For hematopoietic stem and progenitor cells (HSPCs), hypoxia is a specific
microenvironment known as the hypoxic niche. How hypoxia regulates erythroid …
microenvironment known as the hypoxic niche. How hypoxia regulates erythroid …
Efficient terminal erythroid differentiation requires the APC/C cofactor Cdh1 to limit replicative stress in erythroblasts
Abstract The APC/C-Cdh1 ubiquitin ligase complex drives proteosomal degradation of cell
cycle regulators and other cellular proteins during the G1 phase of the cycle. The complex …
cycle regulators and other cellular proteins during the G1 phase of the cycle. The complex …
Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish
Abstract Isocitrate dehydrogenase 1 mutation (IDH1-R132H) was recently identified in acute
myeloid leukemia with normal cytogenetics. The mutant enzyme is thought to convert α …
myeloid leukemia with normal cytogenetics. The mutant enzyme is thought to convert α …
Erythroid differentiation and heme biosynthesis are dependent on a shift in the balance of mitochondrial fusion and fission dynamics
Erythropoiesis is the most robust cellular differentiation and proliferation system, with a
production of∼ 2× 1011 cells per day. In this fine-tuned process, the hematopoietic stem …
production of∼ 2× 1011 cells per day. In this fine-tuned process, the hematopoietic stem …
HDAC6 deacetylates IDH1 to promote the homeostasis of hematopoietic stem and progenitor cells
J Yang, Y Liu, H Yin, S Xie, L Zhang, X Dong, H Ni… - EMBO …, 2023 - embopress.org
Hematopoietic stem and progenitor cells (HSPCs) are cells mainly present in the bone
marrow and capable of forming mature blood cells. However, the epigenetic mechanisms …
marrow and capable of forming mature blood cells. However, the epigenetic mechanisms …