Regulation of α-synuclein (αS) fibril formation is a potent therapeutic strategy for αS-related
neurodegenerative disorders. αS, an intrinsically disordered 140-residue intraneural protein …

Aggregation of neuronal protein α-synuclein leads to the formation of amyloid fibrils, which
are associated with the development of Parkinson's disease. The mechanism of α-synuclein …

α-Synuclein is an intrinsically disordered protein whose aggregation in the form of amyloid
fibers is directly implicated in Parkinson's disease and other neurological disorders. α …

Abstract α-Synuclein (αSyn) is an intrinsically disordered protein that can form amyloid
fibrils. Fibrils of αSyn are implicated with the pathogenesis of Parkinson's disease and other …

Parkinson's disease is characterized by the self-assembly of α-synuclein (AS), in which its
aggregates accumulate in the substantia nigra. The molecular mechanisms of the self …

Increasing evidence suggests that α-synuclein (αS) aggregates in brains of individuals with
Parkinson's disease and dementia with Lewy bodies can spread in a prion-like manner …

Synucleinopathies comprise a diverse group of neurodegenerative diseases including
Parkinson's disease (PD), dementia with Lewy bodies, and multiple system atrophy. These …

The neuronal protein α-synuclein (α-syn) plays a central role in Parkinson's disease (PD).
The pathological features of PD are the loss of dopaminergic neurons in the substantia nigra …

Recent studies revealed that molecular events related with the physiology and pathology of
αS might be regulated by specific sequence motifs in the primary sequence of αS. The …

Amyloid fibril formation of α-synuclein (αS) is associated with multiple neurodegenerative
diseases, including Parkinson's disease (PD). Growing evidence suggests that progression …