The repair of spontaneous or induced DNA damage by homologous recombination (HR) in
Saccharomyces cerevisiae will suppress chromosome rearrangements. Alternative …

The termini of Saccharomyces cerevisiae chromosomes consist of tracts of C1-3A (one to
three cytosine and one adenine residue) sequences of~ 450 base pairs in length. To gain …

Removal of a telomere from yeast chromosome VII in a strain having two copies of this
chromosome often results in its loss. Here we show that there are three pathways that can …

Many Saccharomyces telomeres bear one or more copies of the repetitive Y′ element
followed by∼ 350 bp of telomerase-generated C1–3A/TG1–3 repeats. Although most cells …

To better understand the requirements for telomerase-mediated telomere addition in vivo,
we developed an assay in S. cerevisiae that creates a chromosome end immediately …

Recent work has yielded considerable information concerning the structure and function of
telomeres and their associated sequences in the budding yeast Saccharomyces cerevisiae …

Broken chromosomes healed by de novo addition of a telomere are a major class of
genome rearrangements seen in Saccharomyces cerevisiae and similar to rearrangements …

We have investigated two reactions that occur on telomeric sequences introduced into
Saccharomyces cerevisiae cells by transformation. The elongation reaction added repeats …

Telomerase is a ribonucleoprotein enzyme that adds repetitive sequences to the ends of
linear chromosomes, thereby counteracting nucleotide loss due to incomplete replication. A …

Telomerase adds telomeric DNA repeats to telomeric termini using a sequence within its
RNA subunit as a template. We characterized two mutations in the Kluyveromyces lactis …