Background and aims: Mutations in BRAF have been linked with colorectal cancers (CRC)
showing high level microsatellite instability (MSI-H). However, the distribution of BRAF …

Background & Aims: Recently, an alternative pathway of tumorigenesis has been identified
in the colorectum associated with serrated precursor lesions, variable levels of microsatellite …

Activating mutations of BRAF have been frequently observed in microsatellite unstable
(MSI+) colorectal carcinomas (CRCs), in which mutations of BRAF and KRAS are mutually …

The BRAF oncogene is an integral component of the MAP kinase pathway, and an activating
V600E mutation occurs in 15% of sporadic colorectal cancer. This is an early event in …

BACKGROUND: Colorectal cancer is a heterogeneous disease with multiple underlying
genetic mutations causing different clinical phenotypes. Mutation in the BRAF oncogene is a …

Purpose: The BRAF gene encodes a serine/threonine kinase and plays an important role in
the mitogen-activated protein kinase signaling pathway. BRAF mutations in sporadic …

Background BRAF is a member of RAF family of serine/threonine kinases and mediates
cellular responses to growth signals through the RAS-RAF-MAP kinase pathway. Activating …

The aim of this study was to test the hypothesis that mutations of the oncogenes BRAF or
KRAS are early events in the putative serrated polyp neoplasia pathway and more …

A significant proportion of colorectal cancer (CRC) develops through the serrated neoplasia
pathway. Such tumours show a distinctive molecular phenotype of somatic BRAF mutations …

Background & Aims: Sporadic colorectal cancers with a high degree of microsatellite
instability are a clinically distinct subgroup with a high incidence of BRAF mutation and are …