Atherosclerosis—an immune disease: the Anitschkov Lecture 2007

GK Hansson - Atherosclerosis, 2009 - Elsevier
Atherosclerosis is an inflammatory disease. This article reviews the emergence of this
concept from studies of patients and their lesions, experimental animal models, and …

Mechanisms of disease: the evolving role of regulatory T cells in atherosclerosis

J George - Nature Clinical Practice Cardiovascular Medicine, 2008 - nature.com
Atherosclerosis and related complications still represent the major cause of morbidity and
mortality in the western world. The mechanisms that govern the progression and …

T lymphocytes in atherogenesis—functional aspects and antigenic repertoire

OJ de Boer, AE Becker… - Cardiovascular …, 2003 - academic.oup.com
1. Introduction recognition leads to activation, clonal expansion and/or cytokine production;
in other words, initiating a cell Atherosclerosis represents an inflammatory and repara …

Immunological aspects of atherosclerosis

KJ Woollard - Clinical Science, 2013 - portlandpress.com
Cardiovascular disease is the leading cause of death in several countries. The underlying
process is atherosclerosis, a slowly progressing chronic disorder that can lead to …

The discovery of cellular immunity in the atherosclerotic plaque

GK Hansson, L Jonasson - Arteriosclerosis, thrombosis, and …, 2009 - Am Heart Assoc
It is now generally accepted that atherosclerosis is an inflammatory/immune disease
triggered by LDL accumulation in the artery wall. When discovering T cells and the …

The immune system in atherosclerosis

GK Hansson, A Hermansson - Nature immunology, 2011 - nature.com
Cardiovascular disease, a leading cause of mortality worldwide, is caused mainly by
atherosclerosis, a chronic inflammatory disease of blood vessels. Lesions of atherosclerosis …

Adaptive immunity and atherosclerosis

J Andersson, P Libby, GK Hansson - Clinical immunology, 2010 - Elsevier
Atherosclerosis involves the formation of inflammatory arterial lesions and is one of the most
common causes of death globally. It has been evident for more than 20 years that adaptive …

Immune-inflammatory responses in atherosclerosis: role of an adaptive immunity mainly driven by T and B cells

DA Chistiakov, AN Orekhov, YV Bobryshev - Immunobiology, 2016 - Elsevier
Adaptive immune response plays an important role in atherogenesis. In atherosclerosis, the
proinflammatory immune response driven by Th1 is predominant but the anti-inflammatory …

Inflammation and immune response in atherosclerosis

GK Hansson - Current atherosclerosis reports, 1999 - Springer
Atherosclerosis is an inflammatory disease with a significant autoimmune component.
Studies using transgenic murine models have clarified that recruitment of mononuclear …

Immunological mechanisms in atherosclerosis

T Yokota, GK Hansson - Journal of internal medicine, 1995 - Wiley Online Library
Immunological mechanisms seem to be potent modulators of the atherosclerotic process.
The presence of substantial numbers of T‐lymphocytes in the lesion and local and …