Synucleinopathies are a group of neurodegenerative diseases with common pathological
lesions associated with the excessive accumulation and abnormal intracellular deposition of …

α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve
terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) …

The pathogenesis of many neurodegenerative disorders arises in association with the
misfolding and accumulation of a wide variety of proteins. Much emphasis has been placed …

α-Synuclein is a soluble, natively unfolded protein that is highly enriched in the presynaptic
terminals of neurons in the central nervous system. Interest in α-synuclein has increased …

Parkinson's disease belongs to a group of currently incurable neurodegenerative disorders
characterized by the misfolding and accumulation of alpha‐synuclein aggregates that are …

α-Synuclein is a presynaptic neuronal protein that is linked genetically and
neuropathologically to Parkinson's disease (PD). α-Synuclein may contribute to PD …

α-synuclein is a recently discovered protein that was first identified as the major non amyloid
component of senile plaques, the cerebral lesion likely responsible for Alzheimer's disease …

Genetic, neuropathological and biochemical evidence implicates α-synuclein, a 140 amino
acid presynaptic neuronal protein, in the pathogenesis of Parkinson's disease and other …

Abstract α-Synuclein predominantly expressed in the brain is a small acidic protein
containing three domains namely N-terminal lipid-binding α-helix, amyloid-binding central …

When caused by multiplication mutations of its gene, increased expression of α-synuclein is
associated with familial parkinsonism. Here we discuss the possibility that other …