Phthalate-induced testosterone/androgen receptor pathway disorder on spermatogenesis and antagonism of lycopene
Y Zhao, XN Li, H Zhang, JG Cui, JX Wang… - Journal of Hazardous …, 2022 - Elsevier
Male infertility is an attracting growing concern owing to decline in sperm quality of men
worldwide. Phthalates, in particular to di (2-ethylhexyl) phthalate (DEHP) or its main …
worldwide. Phthalates, in particular to di (2-ethylhexyl) phthalate (DEHP) or its main …
Lycopene prevents DEHP-induced Leydig cell damage with the Nrf2 antioxidant signaling pathway in mice
Y Zhao, MZ Li, Y Shen, J Lin, HR Wang… - Journal of agricultural …, 2019 - ACS Publications
As a plasticizer, di (2-ethylhexyl) phthalate (DEHP) is the most usually used phthalate.
Leydig cell is a male-specific cell, which plays a principal role in spermatogenesis and …
Leydig cell is a male-specific cell, which plays a principal role in spermatogenesis and …
Aryl hydrocarbon receptor as a target for lycopene preventing DEHP-induced spermatogenic disorders
Y Zhao, J Lin, M Talukder, SY Zhu, MZ Li… - Journal of agricultural …, 2020 - ACS Publications
Di (2-ethylhexyl) phthalate (DEHP) is widely used as a plasticizer to improve product
flexibility and workability. Lycopene (LYC) is a natural compound and has promising …
flexibility and workability. Lycopene (LYC) is a natural compound and has promising …
Di-(2-ethylhexyl) phthalate inhibits testosterone level through disturbed hypothalamic–pituitary–testis axis and ERK-mediated 5α-Reductase 2
M Ha, X Guan, L Wei, P Li, M Yang, C Liu - Science of the total environment, 2016 - Elsevier
Abstract Di-(2-ethylhexyl) phthalate (DEHP) has reproductive toxicity and can affect male
reproductive development. In order to clarify adverse effects of DEHP on testicular …
reproductive development. In order to clarify adverse effects of DEHP on testicular …
Di-2-ethylhexyl phthalate (DEHP) exposure induces sperm quality and functional defects in mice
L XueXia, L YaNan, T Zi, Z YuSheng, W ZeLin, Z Peng… - Chemosphere, 2023 - Elsevier
Abstract Di-2-ethylhexyl phthalate (DEHP) harms mammalian testis development, yet the
specific mechanism of its effect on sperm quality and function is unclear. In this study, male …
specific mechanism of its effect on sperm quality and function is unclear. In this study, male …
[HTML][HTML] Exposure to DEHP induces testis toxicity and injury through the ROS/mTOR/NLRP3 signaling pathway in immature rats
Y Hong, Y Zhou, L Shen, Y Wei, C Long, Y Fu… - Ecotoxicology and …, 2021 - Elsevier
As the most abundantly used phthalate derivative, di-(2-ethylhexyl) phthalate (DEHP) leads
to reproductive disorders, especially in males. Testicular injury can be triggered when the …
to reproductive disorders, especially in males. Testicular injury can be triggered when the …
DEHP induces ferroptosis in testes via p38α-lipid ROS circulation and destroys the BTB integrity
L Yang, L Jiang, X Sun, J Li, N Wang, X Liu… - Food and Chemical …, 2022 - Elsevier
Abstract Exposure to Di (2-ethylhexyl) phthalate (DEHP) has been associated with toxic
effects of the reproductive system. However, the exact mechanism remains to be elucidated …
effects of the reproductive system. However, the exact mechanism remains to be elucidated …
Vitamin E and vitamin C attenuate Di-(2-ethylhexyl) phthalate-induced blood-testis barrier disruption by p38 MAPK in immature SD rats
L Shen, X Tang, Y Wei, C Long, B Tan, S Wu… - Reproductive …, 2018 - Elsevier
As an environmental endocrine disruptor, Di-(2-ethylhexyl) phthalate (DEHP) affects blood-
testis barrier (BTB)-associated proteins expression, which compromises BTB integrity and …
testis barrier (BTB)-associated proteins expression, which compromises BTB integrity and …
Dibutyl phthalate induces oxidative stress and impairs spermatogenesis in adult rats
HAA Aly, MH Hassan… - Toxicology and …, 2016 - journals.sagepub.com
Phthalates are abundantly produced plasticizers, and dibutyl phthalate (DBP) is the most
widely used derivative in various consumer products and medical devices. This study was …
widely used derivative in various consumer products and medical devices. This study was …
Phthalate exposure in association with serum hormone levels, sperm DNA damage and spermatozoa apoptosis: A cross-sectional study in China
Exposure to phthalates has been demonstrated to cause reproductive toxicity in animals, but
evidence of the association between phthalates and markers of male reproductive function …
evidence of the association between phthalates and markers of male reproductive function …