Regulation of intestinal lipid metabolism: current concepts and relevance to disease

CW Ko, J Qu, DD Black, P Tso - Nature Reviews Gastroenterology & …, 2020 - nature.com
Lipids entering the gastrointestinal tract include dietary lipids (triacylglycerols, cholesteryl
esters and phospholipids) and endogenous lipids from bile (phospholipids and cholesterol) …

Recent advances in triacylglycerol mobilization by the gut

C Xiao, P Stahel, AL Carreiro, KK Buhman… - Trends in Endocrinology …, 2018 - cell.com
Dietary lipid absorption and lipoprotein secretion by the gut are important in maintaining
whole-body energy homeostasis and have significant implications for health and disease …

Jejunum: The understudied meeting place of dietary lipids and the microbiota

I Lema, JR Araújo, N Rolhion, S Demignot - Biochimie, 2020 - Elsevier
Although the jejunum is the main intestinal compartment responsible for lipid digestion and
absorption, most of the studies assessing the impact of dietary lipids on the intestinal …

When fat meets the gut—focus on intestinal lipid handling in metabolic health and disease

M Wit, J Trujillo‐Viera, A Strohmeyer… - EMBO Molecular …, 2022 - embopress.org
The regular overconsumption of energy‐dense foods (rich in lipids and sugars) results in
elevated intestinal nutrient absorption and consequently excessive accumulation of lipids in …

Gut microbiome lipid metabolism and its impact on host physiology

EM Brown, J Clardy, RJ Xavier - Cell Host & Microbe, 2023 - cell.com
Metabolites produced by commensal gut microbes impact host health through their
recognition by the immune system and their influence on numerous metabolic pathways …

Gut microbiome and lipid metabolism: from associations to mechanisms

Z Wang, D Koonen, M Hofker, J Fu - Current opinion in lipidology, 2016 - journals.lww.com
The gut microbiome is transitioning from being a 'missing'organ to a potential target for
therapeutic applications. Due to the complex interplay between the gut microbiome, the host …

Role of the gut in lipid homeostasis

NA Abumrad, NO Davidson - Physiological reviews, 2012 - journals.physiology.org
Intestinal lipid transport plays a central role in fat homeostasis. Here we review the pathways
regulating intestinal absorption and delivery of dietary and biliary lipid substrates, principally …

Linking gut microbiome and lipid metabolism: moving beyond associations

S Lamichhane, P Sen, MA Alves, HC Ribeiro… - Metabolites, 2021 - mdpi.com
Various studies aiming to elucidate the role of the gut microbiome-metabolome co-axis in
health and disease have primarily focused on water-soluble polar metabolites, whilst non …

The gut-liver axis

RGJ Visschers, MD Luyer, FG Schaap… - Current Opinion in …, 2013 - journals.lww.com
Enteral lipids reduce inflammation and liver damage during stress or systemic inflammation,
whereas parenteral lipid is associated with liver damage. Maintaining the enterohepatic …

Physiology and pathophysiology of liver lipid metabolism

FR Ponziani, S Pecere, A Gasbarrini… - Expert review of …, 2015 - Taylor & Francis
Liver lipid metabolism and its modulation are involved in many pathologic conditions, such
as obesity, non-alcoholic fatty liver disease, diabetes mellitus, atherosclerosis and …