The past decade has revealed neuroinflammation as an important mechanism of major
depressive disorder (MDD). Nod-like receptors family pyrin domain containing 3 (NLRP3) …

Background Major depressive disorder (MDD) is a common but severe psychiatric illness
characterized by depressive mood and diminished interest. Both nucleotide-binding …

Abstract Major Depressive Disorder (MDD, ICD-10: F-33) is a prevalent illness in which the
pathogenic mechanism remains elusive. Recently an important role has been attributed to …

Increasing evidence suggests that the failure of clinical antidepressants may be related with
neuroinflammation. The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) …

Major depressive disorder (MDD) is a highly prevalent psychiatric disorder, whose
pathophysiology has been linked to the neuroinflammatory process. The increased activity …

Autophagy degrades phagocytosed damaged organelles, misfolded proteins, and various
pathogens through lysosomes as an essential way to maintain cellular homeostasis …

Abstract In the Central Nervous System (CNS), neuroinflammation orchestrated by microglia
and astrocytes is an innate immune response to counteract stressful and dangerous insults …

Over the past three decades, an intricate interaction between immune activation, release of
pro-inflammatory cytokines and changes in brain circuits related to mood and behavior has …

Depression holds the title of the largest contributor to worldwide disability, with the numbers
expected to continue growing. Currently, there are neither reliable biomarkers for the …

NLRP3 inflammasome pathway-mediated inflammatory response is closely associated with
depression. Increasing attention has been recently paid to the links between autophagy and …