The interaction between autophagy and neuroinflammation in major depressive disorder: from pathophysiology to therapeutic implications
M Tang, T Liu, P Jiang, R Dang - Pharmacological research, 2021 - Elsevier
The past decade has revealed neuroinflammation as an important mechanism of major
depressive disorder (MDD). Nod-like receptors family pyrin domain containing 3 (NLRP3) …
depressive disorder (MDD). Nod-like receptors family pyrin domain containing 3 (NLRP3) …
[HTML][HTML] Autophagy dysfunction contributes to NLRP1 inflammasome-linked depressive-like behaviors in mice
YJ Zhu, J Huang, R Chen, Y Zhang, X He… - Journal of …, 2024 - Springer
Background Major depressive disorder (MDD) is a common but severe psychiatric illness
characterized by depressive mood and diminished interest. Both nucleotide-binding …
characterized by depressive mood and diminished interest. Both nucleotide-binding …
Antidepressants induce autophagy dependent-NLRP3-inflammasome inhibition in Major depressive disorder
E Alcocer-Gómez, N Casas-Barquero… - Pharmacological …, 2017 - Elsevier
Abstract Major Depressive Disorder (MDD, ICD-10: F-33) is a prevalent illness in which the
pathogenic mechanism remains elusive. Recently an important role has been attributed to …
pathogenic mechanism remains elusive. Recently an important role has been attributed to …
[HTML][HTML] The NLRP3 inflammasome in depression: potential mechanisms and therapies
CY Xia, YX Guo, WW Lian, Y Yan, BZ Ma… - Pharmacological …, 2023 - Elsevier
Increasing evidence suggests that the failure of clinical antidepressants may be related with
neuroinflammation. The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) …
neuroinflammation. The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) …
[HTML][HTML] NLRP3 inflammasome: from pathophysiology to therapeutic target in major depressive disorder
BR Kouba, J Gil-Mohapel, AL S. Rodrigues - International journal of …, 2022 - mdpi.com
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder, whose
pathophysiology has been linked to the neuroinflammatory process. The increased activity …
pathophysiology has been linked to the neuroinflammatory process. The increased activity …
[HTML][HTML] Interaction between autophagy and the NLRP3 inflammasome in Alzheimer's and Parkinson's disease
R Lu, L Zhang, X Yang - Frontiers in Aging Neuroscience, 2022 - frontiersin.org
Autophagy degrades phagocytosed damaged organelles, misfolded proteins, and various
pathogens through lysosomes as an essential way to maintain cellular homeostasis …
pathogens through lysosomes as an essential way to maintain cellular homeostasis …
The role of dopamine in NLRP3 inflammasome inhibition: Implications for neurodegenerative diseases
Abstract In the Central Nervous System (CNS), neuroinflammation orchestrated by microglia
and astrocytes is an innate immune response to counteract stressful and dangerous insults …
and astrocytes is an innate immune response to counteract stressful and dangerous insults …
NLRP3 inflammasome-driven pathways in depression: clinical and preclinical findings
Over the past three decades, an intricate interaction between immune activation, release of
pro-inflammatory cytokines and changes in brain circuits related to mood and behavior has …
pro-inflammatory cytokines and changes in brain circuits related to mood and behavior has …
NLRP3 inflammatory pathway. Can we unlock depression?
GG Jahromi, S Razi, N Rezaei - Brain Research, 2023 - Elsevier
Depression holds the title of the largest contributor to worldwide disability, with the numbers
expected to continue growing. Currently, there are neither reliable biomarkers for the …
expected to continue growing. Currently, there are neither reliable biomarkers for the …
Lysosomal dysfunction is associated with NLRP3 inflammasome activation in chronic unpredictable mild stress-induced depressive mice
MM Li, X Wang, XD Chen, HL Yang, HS Xu… - Behavioural Brain …, 2022 - Elsevier
NLRP3 inflammasome pathway-mediated inflammatory response is closely associated with
depression. Increasing attention has been recently paid to the links between autophagy and …
depression. Increasing attention has been recently paid to the links between autophagy and …