PURPOSE: Delirium is a common complication in postoperative critically ill patients.
Although abnormal melatonin metabolism is thought to be one of the mechanisms of …

Objective Postoperative delirium (POD) is a perennial and distressing complication in older
patients, and it may be caused by various factors. This study aimed to determine whether …

Background: Melatonin, a hormone produced in the pineal gland, is involved in circadian
rhythms and the sleep-wake cycle. Postoperative delirium is encountered frequently in …

Background Abolished circadian rhythm is associated with altered cognitive function,
delirium, and as a result increased mortality in critically ill patients, especially in those who …

Results: The incidence of delirium was 8.4% in the melatonin group vs. 20.8% in the control
group (p= 0.001). Predictors of delirium in the melatonin group were age (p= 0.001) and …

There is increasing interest in the hormone melatonin in postoperative and critically ill
patients. The roles of melatonin in the regulation of the sleep-wake cycle, resetting of …

Study Objective Intensive care unit (ICU) delirium is an acute brain dysfunction that has
been associated with increased mortality, prolonged ICU and hospital lengths of stay, and …

Background Older surgical patients are at high risk of developing postoperative delirium.
Non-pharmacological strategies are recommended for delirium prevention, but no …

Discussion The incidence of postoperative delirium in patients undergoing surgery for hip
fracture by spinal or general anesthesia is reported at 16%–41%, beginning usually one or …

Introduction Delirium is highly prevalent in the intensive care unit (ICU) and is associated
with adverse clinical outcomes. At this time, there is no drug that effectively prevents delirium …