Celecoxib induces proliferation and Amphiregulin production in colon subepithelial myofibroblasts, activating erk1–2 signaling in synergy with EGFR
The COX-2 inhibitor Celecoxib, tested in phase III trials for the prevention of sporadic colon
adenomas, reduced the appearance of new adenomas, but was unable to affect the …
adenomas, reduced the appearance of new adenomas, but was unable to affect the …
Chronic cyclooxygenase-2 inhibition promotes myofibroblast-associated intestinal fibrosis
JS Davids, AM Carothers, BC Damas… - Cancer Prevention …, 2010 - AACR
Anti-inflammatory drugs prevent intestinal tumor formation, an activity related to their ability
to inhibit inflammatory pathway signaling in the target tissue. We previously showed that …
to inhibit inflammatory pathway signaling in the target tissue. We previously showed that …
TNF-α and LPA promote synergistic expression of COX-2 in human colonic myofibroblasts: role of LPA-mediated transactivation of upregulated EGFR
J Yoo, CE Rodriguez Perez, W Nie, J Sinnett-Smith… - BMC …, 2013 - Springer
Abstract Background Enhanced EGF receptor (EGFR) signaling is a hallmark of many
human cancers, though the role of enhanced EGFR signaling within the surrounding tumor …
human cancers, though the role of enhanced EGFR signaling within the surrounding tumor …
Subepithelial myofibroblasts express cyclooxygenase-2 in colorectal tubular adenomas
PA Adegboyega, O Ololade, J Saada, R Mifflin… - Clinical cancer …, 2004 - AACR
Purpose: Recent data support the hypothesis that the inducible isoform of cyclooxygenase
(COX-2) plays a role in the early stages of colonic carcinogenesis and that nonsteroidal anti …
(COX-2) plays a role in the early stages of colonic carcinogenesis and that nonsteroidal anti …
[HTML][HTML] Celecoxib increases EGF signaling in colon tumor associated fibroblasts, modulating EGFR expression and degradation
We previously demonstrated that non-toxic doses of Celecoxib induced the immediate
phosphorylation of Erk1-2 in colon tumor associated fibroblasts (TAFs), increasing their …
phosphorylation of Erk1-2 in colon tumor associated fibroblasts (TAFs), increasing their …
[HTML][HTML] Regulation of intestinal myofibroblasts by KRas-mutated colorectal cancer cells through heparin-binding epidermal growth factor-like growth factor
H Kawasaki, T Saotome, T Usui… - Oncology …, 2017 - spandidos-publications.com
In colorectal cancer, gain-of-function mutations in KRas play a critical role in malignant
transformation. Tumor growth in colorectal cancer is known to be promoted by the intestinal …
transformation. Tumor growth in colorectal cancer is known to be promoted by the intestinal …
Persistent cyclooxygenase-2 inhibition downregulates NF-κB, resulting in chronic intestinal inflammation in the min/+ mouse model of colon tumorigenesis
AM Carothers, JS Davids, BC Damas, MM Bertagnolli - Cancer research, 2010 - AACR
Abstract Cyclooxygenase-2 (COX-2) inhibition prevents adenoma formation in humans and
mouse models of colon cancer. The selective COX-2 inhibitor celecoxib reduces COX-2 and …
mouse models of colon cancer. The selective COX-2 inhibitor celecoxib reduces COX-2 and …
Roles of Myofibroblasts in Prostaglandin E2–Stimulated Intestinal Epithelial Proliferation and Angiogenesis
J Shao, GG Sheng, RC Mifflin, DW Powell, H Sheng - Cancer research, 2006 - AACR
Prostaglandins (PG) are produced throughout the gastrointestinal tract and are critical
mediators for a complex array of physiologic and pathophysiologic processes in the …
mediators for a complex array of physiologic and pathophysiologic processes in the …
Gene expression analysis proposes alternative pathways for the mechanism by which celecoxib selectively inhibits the growth of transformed but not normal …
E Sagiv, U Rozovski, D Kazanov, E Liberman… - Clinical cancer …, 2007 - AACR
Abstract Purpose: Cyclooxygenase-2 inhibitor (celecoxib, Pfizer) is a promising
chemopreventive agent, yet its long-term use may be limited due to increased …
chemopreventive agent, yet its long-term use may be limited due to increased …
PPAR-gamma is expressed and NF-kB pathway is activated and correlates positively with COX-2 expression in stromal myofibroblasts surrounding colon …
GP Vandoros, PA Konstantinopoulos… - Journal of cancer …, 2006 - Springer
Purpose: Accumulated evidence indicates that carcinogenesis is closely associated with the
transformation of normal stroma into a 'reactive'stromal phenotype. The present study …
transformation of normal stroma into a 'reactive'stromal phenotype. The present study …