Emerging principles of cytokine pharmacology and therapeutics
Cytokines are secreted signalling proteins that play essential roles in the initiation,
maintenance and resolution of immune responses. Although the unique ability of cytokines …
maintenance and resolution of immune responses. Although the unique ability of cytokines …
Strategies to therapeutically modulate cytokine action
WJ Leonard, JX Lin - Nature Reviews Drug Discovery, 2023 - nature.com
Cytokines are secreted or membrane-presented molecules that mediate broad cellular
functions, including development, differentiation, growth and survival. Accordingly, the …
functions, including development, differentiation, growth and survival. Accordingly, the …
Insights into cytokine–receptor interactions from cytokine engineering
Cytokines exert a vast array of immunoregulatory actions critical to human biology and
disease. However, the desired immunotherapeutic effects of native cytokines are often …
disease. However, the desired immunotherapeutic effects of native cytokines are often …
Engineering strategies for immunomodulatory cytokine therapies: challenges and clinical progress
Cytokines are immunoregulatory proteins involved in many pathological states with
promising potential as therapeutic agents. A diverse array of cytokines has been studied in …
promising potential as therapeutic agents. A diverse array of cytokines has been studied in …
Fine-tuning cytokine signals
JX Lin, WJ Leonard - Annual review of immunology, 2019 - annualreviews.org
Cytokines are secreted or otherwise released polypeptide factors that exert autocrine and/or
paracrine actions, with most cytokines acting in the immune and/or hematopoietic system …
paracrine actions, with most cytokines acting in the immune and/or hematopoietic system …
Small molecules to the rescue: Inhibition of cytokine signaling in immune-mediated diseases
M Gadina, N Gazaniga, L Vian, Y Furumoto - Journal of autoimmunity, 2017 - Elsevier
Cytokines are small, secreted proteins associated with the maintenance of immune
homeostasis but also implicated with the pathogenesis of several autoimmune and …
homeostasis but also implicated with the pathogenesis of several autoimmune and …
Signalling platforms that modulate the inflammatory response: new targets for drug development
CA McCulloch, GP Downey… - Nature reviews Drug …, 2006 - nature.com
Therapeutically controlling inflammation is essential for the clinical management of many
high-prevalence human diseases. Drugs that block the pro-inflammatory cytokines tumour …
high-prevalence human diseases. Drugs that block the pro-inflammatory cytokines tumour …
Cytokines and cytokine receptors
Cytokines are critical mediators of communication for the immune system, and they are
essential for host defense against pathogens. Cytokines can be secreted by immune cells …
essential for host defense against pathogens. Cytokines can be secreted by immune cells …
Structural basis of IL-1 family cytokine signaling
Interleukin-1 (IL-1) family cytokines are key signaling molecules in both the innate and
adaptive immune systems, mediating inflammation in response to a wide range of stimuli …
adaptive immune systems, mediating inflammation in response to a wide range of stimuli …
Cytokines: past, present, and future
JJ Oppenheim - International journal of hematology, 2001 - Springer
This review provides an historical account of the discovery and development of cytokines.
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular …
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular …