Pervasive transcription of eukaryotic genomes stems to a large extent from bidirectional
promoters that synthesize mRNA and divergent noncoding RNA (ncRNA). Here, we show …

Abstract Background Nrd1 and Nab3 are essential sequence-specific yeast RNA binding
proteins that function as a heterodimer in the processing and degradation of diverse classes …

RNA polymerase II transcribes both coding and noncoding genes, and termination of these
different classes of transcripts is facilitated by different sets of termination factors. Pre …

Pervasive transcription is now accepted to be a general feature of eukaryotic genomes,
generating short and long non-coding RNAs (ncRNAs). Growing number of examples have …

Antisense long non-coding (aslnc) RNAs represent a substantial part of eukaryotic
transcriptomes that are, in yeast, controlled by the Xrn1 exonuclease. Nonsense-Mediated …

In eukaryotes, an elaborate set of mechanisms has evolved to ensure that the multistep
process of gene expression is accurately executed and adapted to cellular needs. The …

In addition to their annotated transcript, many eukaryotic mRNA promoters produce
divergent noncoding transcripts. To define determinants of divergent promoter directionality …

Metazoan genomes are broadly transcribed by RNA polymerase II (RNAPII), but surprisingly
few of these RNAs encode proteins. Accordingly, there is great interest in understanding the …

Eukaryotic genomes generate a heterogeneous ensemble of mRNAs and long noncoding
RNAs (lncRNAs). LncRNAs and mRNAs are both transcribed by Pol II and acquire 5′ caps …

Eukaryotic cells synthesize enormous quantities of RNA from diverse classes, most of which
are subject to extensive processing. These processes are inherently error-prone, and cells …