Iron is essential for the survival of most bacteria but presents a significant challenge given its
limited bioavailability. Furthermore, the toxicity of iron combined with the need to maintain …

In bacteria, the fine balance of maintaining adequate iron levels while preventing the
deleterious effects of excess iron has led to the evolution of sophisticated cellular …

Iron is a transition metal utilized by nearly all forms of life for essential cellular processes,
such as DNA synthesis and cellular respiration. During infection by bacterial pathogens, the …

All but a few bacterial species have an absolute need for heme, and most are able to
synthesize it via a pathway that is highly conserved among all life domains. Because heme …

Covering: 2000–2006 The ability of bacterial pathogens to obtain iron is essential for their
survival, and the expression of such virulence factors is (in part) essential for establishing …

Efficient iron acquisition is critical for an invading microbe's survival and virulence. Most of
the iron in mammals is incorporated into heme, which can be plundered by certain bacterial …

Bacteria that reside in animal tissues and/or cells must acquire iron from their host. However,
almost all of the host iron is sequestered in iron-containing compounds and proteins, the …

Iron is a versatile redox-active catalyst and a required cofactor within a diverse array of
biological processes. To almost all organisms, iron is both essential and potentially toxic …

Gram‐negative pathogenic bacteria have evolved novel strategies to obtain iron from host
haem‐sequestering proteins. These include the production of specific outer membrane …

Highlights•HmuUV is the first structure of a heme uptake inner membrane ABC
transporter.•A novel assay was developed to assess in vitro heme uptake for …