Changes in α-Synuclein Posttranslational Modifications in an AAV-Based Mouse Model of Parkinson's Disease

V Brembati, G Faustini, F Longhena, TF Outeiro… - International Journal of …, 2023 - mdpi.com
Parkinson's disease (PD) pathology is characterized by the loss of dopaminergic neurons of
the nigrostriatal system and accumulation of Lewy bodies (LB) and Lewy neurites (LN) …

Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression

M Bourdenx, S Dovero, M Engeln, S Bido… - Acta neuropathologica …, 2015 - Springer
Introduction Parkinson's disease (PD) is a progressive neurodegenerative disorder
characterized by the loss of dopaminergic neurons as well as the presence of proteinaceous …

Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal system

SE Gombash, FP Manfredsson, CJ Kemp, NC Kuhn… - PloS one, 2013 - journals.plos.org
The discovery of the involvement of alpha-synuclein (α-syn) in Parkinson's disease (PD)
pathogenesis has resulted in the development and use of viral vector-mediated α-syn …

Modeling Parkinson's disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain

P Thakur, LS Breger, M Lundblad… - Proceedings of the …, 2017 - National Acad Sciences
Although a causative role of α-synuclein (α-syn) is well established in Parkinson's disease
pathogenesis, available animal models of synucleinopathy do not replicate the full range of …

Modeling Parkinson's disease with the alpha-synuclein protein

M Gómez-Benito, N Granado, P García-Sanz… - Frontiers in …, 2020 - frontiersin.org
Alpha-synuclein (α-Syn) is a key protein involved in Parkinson's disease (PD) pathology. PD
is characterized by the loss of dopaminergic neuronal cells in the substantia nigra pars …

Co‐expression of C‐terminal truncated alpha‐synuclein enhances full‐length alpha‐synuclein‐induced pathology

A Ulusoy, F Febbraro, PH Jensen… - European Journal of …, 2010 - Wiley Online Library
Lewy bodies, which are a pathological hallmark of Parkinson's disease, contain insoluble
polymers of alpha‐synuclein (αsyn). Among the different modifications that can promote the …

α-Synuclein: Multiple pathogenic roles in trafficking and proteostasis pathways in Parkinson's disease

AJ Zalon, DJ Quiriconi, C Pitcairn… - The …, 2024 - journals.sagepub.com
Parkinson's disease (PD) is a common age-related neurodegenerative disorder
characterized by the loss of dopaminergic neurons in the midbrain. A hallmark of both …

Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease

KL Paumier, SJ Sukoff Rizzo, Z Berger, Y Chen… - PloS one, 2013 - journals.plos.org
Parkinson's disease (PD) pathology is characterized by the formation of intra-neuronal
inclusions called Lewy bodies, which are comprised of alpha-synuclein (α-syn). Duplication …

α-Synuclein and nonhuman primate models of Parkinson's disease

SC Vermilyea, ME Emborg - Journal of neuroscience methods, 2015 - Elsevier
Accumulation of α-synuclein (α-syn) leading to the formation of insoluble intracellular
aggregates named Lewy bodies is proposed to have a significant role in Parkinson's …

“Janus-Faced” α-synuclein: role in Parkinson's disease

B Ray, AM Mahalakshmi, S Tuladhar, A Bhat… - Frontiers in Cell and …, 2021 - frontiersin.org
Parkinson's disease (PD) is a pathological condition characterized by the aggregation and
the resultant presence of intraneuronal inclusions termed Lewy bodies (LBs) and Lewy …