Development and optimization of a methodology to synthetize chitosan/cetuximab conjugates for encapsulate siRNA and targeting to EGFR overexpressing cells
JAP Mota - 2014 - repositorio.cespu.pt
O uso terapêutico de Small Interfering RNA (siRNA) tem sido observado como uma
potencial nova abordagem para o tratamento do cancro. O desafio-chave no campo clínico …
potencial nova abordagem para o tratamento do cancro. O desafio-chave no campo clínico …
Chitosan-based siRNA delivery systems
Recently, chitosan has attracted significant attention in the formulation of small interfering
RNA (siRNA). Because of its cationic nature, chitosan can easily complex siRNA, thus …
RNA (siRNA). Because of its cationic nature, chitosan can easily complex siRNA, thus …
Chitosan nanoplexes for target siRNA delivery
A Gutoaia - 2016 - tobias-lib.ub.uni-tuebingen.de
In recent years biopharmaceutical companies have started to turn their attention towards
small interfering RNA (siRNA) therapeutics, as they offer a strategy to address …
small interfering RNA (siRNA) therapeutics, as they offer a strategy to address …
Advances in targeted delivery of small interfering RNA using simple bioconjugates
C Nielsen, J Kjems, KR Sørensen… - Expert Opinion on …, 2014 - Taylor & Francis
Introduction: Development of drugs based on RNA interference by small interfering RNA
(siRNA) has been progressing slowly due to a number of challenges associated with the in …
(siRNA) has been progressing slowly due to a number of challenges associated with the in …
PEGylation of biodegradable dextran nanogels for siRNA delivery
B Naeye, K Raemdonck, K Remaut, B Sproat… - European journal of …, 2010 - Elsevier
Delivering intact small interfering RNA (siRNA) into the cytoplasm of targeted cells in vivo is
considered a major obstacle in the development of clinically applicable RNA interference …
considered a major obstacle in the development of clinically applicable RNA interference …
Chitosan-Based Nanocarriers for Efficient and Targeted siRNA Delivery
RNA interference mediated by small interfering RNAs (siRNA) is rapidly emerging as
promising therapeutic strategy for the treatment of inherited and acquired diseases, such as …
promising therapeutic strategy for the treatment of inherited and acquired diseases, such as …
Targeted delivery of small interfering RNA to colon cancer cells using chitosan and PEGylated chitosan nanoparticles
WE Rudzinski, A Palacios, A Ahmed, MA Lane… - Carbohydrate …, 2016 - Elsevier
Small interfering RNA (siRNA) molecules specifically target messenger RNA species,
decreasing intracellular protein levels. β-Catenin protein concentrations are increased in 70 …
decreasing intracellular protein levels. β-Catenin protein concentrations are increased in 70 …
RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system
KA Howard, UL Rahbek, X Liu, CK Damgaard… - Molecular Therapy, 2006 - cell.com
This work introduces a novel chitosan-based siRNA nanoparticle delivery system for RNA
interference in vitro and in vivo. The formation of interpolyelectrolyte complexes between …
interference in vitro and in vivo. The formation of interpolyelectrolyte complexes between …
Biomedical application of chitosan-based nanoscale delivery systems: Potential usefulness in siRNA delivery for cancer therapy
Gene therapy is an emerging and promising strategy in cancer therapy where small
interfering RNA (siRNA) system has been deployed for down-regulation of targeted gene …
interfering RNA (siRNA) system has been deployed for down-regulation of targeted gene …
T cell-specific siRNA delivery using antibody-conjugated chitosan nanoparticles
J Lee, KS Yun, CS Choi, SH Shin, HS Ban… - Bioconjugate …, 2012 - ACS Publications
The intracellular delivery of small interfering RNA (siRNA) plays a key role in RNA
interference (RNAi) and provides an emerging technique to treat various diseases, including …
interference (RNAi) and provides an emerging technique to treat various diseases, including …