[HTML][HTML] Active caspase-1 is a regulator of unconventional protein secretion
M Keller, A Rüegg, S Werner, HD Beer - Cell, 2008 - cell.com
Mammalian cells export most proteins by the endoplasmic reticulum/Golgi-dependent
pathway. However, some proteins are secreted via unconventional, poorly understood …
pathway. However, some proteins are secreted via unconventional, poorly understood …
Caspase-1 as a multifunctional inflammatory mediator: noncytokine maturation roles
Caspase-1 is an inflammatory caspase that is activated through formation of inflammasome
complexes in response to both pathogen-derived and endogenous mediators. The most well …
complexes in response to both pathogen-derived and endogenous mediators. The most well …
[HTML][HTML] Caspase-2 substrates: to apoptosis, cell cycle control, and beyond
AN Brown-Suedel, L Bouchier-Hayes - Frontiers in Cell and …, 2020 - frontiersin.org
Caspase-2 belongs to the caspase family of proteins responsible for essential cellular
functions including apoptosis and inflammation. Uniquely, caspase-2 has been identified as …
functions including apoptosis and inflammation. Uniquely, caspase-2 has been identified as …
The role of caspase‐2 in stress‐induced apoptosis
L Bouchier‐Hayes - Journal of cellular and molecular medicine, 2010 - Wiley Online Library
Caspase function• Caspase‐2: Initiator or executioner caspase?• Functions of caspase‐2‐
Role in development‐Caspase‐2 in aging‐Caspase‐2 is a tumour suppressor‐Caspase‐2 …
Role in development‐Caspase‐2 in aging‐Caspase‐2 is a tumour suppressor‐Caspase‐2 …
Caspase-1: the inflammasome and beyond
G Sollberger, GE Strittmatter, M Garstkiewicz… - Innate …, 2014 - journals.sagepub.com
Caspase-1 plays a fundamental role in innate immunity and in several important
inflammatory diseases as the protease activates the pro-inflammatory cytokines proIL-1β …
inflammatory diseases as the protease activates the pro-inflammatory cytokines proIL-1β …
Caspase-1: an integral regulator of innate immunity
S Winkler, A Rösen-Wolff - Seminars in immunopathology, 2015 - Springer
Caspase-1 is a unique cysteine protease playing central roles in innate immunity.
Pathogens, stress, and damage signals induce activation of caspase-1, typically mediated …
Pathogens, stress, and damage signals induce activation of caspase-1, typically mediated …
[HTML][HTML] Caspases connect cell-death signaling to organismal homeostasis
Some forms of regulated cell death, such as apoptosis, are precipitated by the activation of
cysteine proteases of the caspase family, including caspase 8, 9, and 3. Other caspases …
cysteine proteases of the caspase family, including caspase 8, 9, and 3. Other caspases …
[HTML][HTML] Human caspases: activation, specificity, and regulation
C Pop, GS Salvesen - Journal of biological Chemistry, 2009 - ASBMB
Caspases are intracellular proteases that propagate programmed cell death, proliferation,
and inflammation. Activation of caspases occurs by a conserved mechanism subject to strict …
and inflammation. Activation of caspases occurs by a conserved mechanism subject to strict …
[HTML][HTML] Old, new and emerging functions of caspases
Caspases are proteases with a well-defined role in apoptosis. However, increasing
evidence indicates multiple functions of caspases outside apoptosis. Caspase-1 and …
evidence indicates multiple functions of caspases outside apoptosis. Caspase-1 and …