Mammalian cells export most proteins by the endoplasmic reticulum/Golgi-dependent
pathway. However, some proteins are secreted via unconventional, poorly understood …

Caspase-1 is an inflammatory caspase that is activated through formation of inflammasome
complexes in response to both pathogen-derived and endogenous mediators. The most well …

Caspase-2 belongs to the caspase family of proteins responsible for essential cellular
functions including apoptosis and inflammation. Uniquely, caspase-2 has been identified as …

Caspase function• Caspase‐2: Initiator or executioner caspase?• Functions of caspase‐2‐
Role in development‐Caspase‐2 in aging‐Caspase‐2 is a tumour suppressor‐Caspase‐2 …

Caspase-1 plays a fundamental role in innate immunity and in several important
inflammatory diseases as the protease activates the pro-inflammatory cytokines proIL-1β …

Caspase-1 is a unique cysteine protease playing central roles in innate immunity.
Pathogens, stress, and damage signals induce activation of caspase-1, typically mediated …

Caspase-2 Caspase-2, formerly known as ICH-1 (Wang et al., 1994) or NEDD-2 (Kumar et
al., 1994), is a highly conserved but functionally poorly defined member of the caspase …

Some forms of regulated cell death, such as apoptosis, are precipitated by the activation of
cysteine proteases of the caspase family, including caspase 8, 9, and 3. Other caspases …

Caspases are intracellular proteases that propagate programmed cell death, proliferation,
and inflammation. Activation of caspases occurs by a conserved mechanism subject to strict …

Caspases are proteases with a well-defined role in apoptosis. However, increasing
evidence indicates multiple functions of caspases outside apoptosis. Caspase-1 and …