Heme synthesis and acquisition in bacterial pathogens
Bacterial pathogens require the iron-containing cofactor heme to cause disease. Heme is
essential to the function of hemoproteins, which are involved in energy generation by the …
essential to the function of hemoproteins, which are involved in energy generation by the …
Heme and virulence: how bacterial pathogens regulate, transport and utilize heme
A Wilks, KA Burkhard - Natural product reports, 2007 - pubs.rsc.org
Covering: 2000–2006 The ability of bacterial pathogens to obtain iron is essential for their
survival, and the expression of such virulence factors is (in part) essential for establishing …
survival, and the expression of such virulence factors is (in part) essential for establishing …
Heme uptake and utilization by gram-negative bacterial pathogens
KL Richard, BR Kelley, JG Johnson - Frontiers in cellular and …, 2019 - frontiersin.org
Iron is a transition metal utilized by nearly all forms of life for essential cellular processes,
such as DNA synthesis and cellular respiration. During infection by bacterial pathogens, the …
such as DNA synthesis and cellular respiration. During infection by bacterial pathogens, the …
Role and regulation of heme iron acquisition in gram-negative pathogens
LJ Runyen-Janecky - Frontiers in cellular and infection microbiology, 2013 - frontiersin.org
Bacteria that reside in animal tissues and/or cells must acquire iron from their host. However,
almost all of the host iron is sequestered in iron-containing compounds and proteins, the …
almost all of the host iron is sequestered in iron-containing compounds and proteins, the …
Heme uptake in bacterial pathogens
H Contreras, N Chim, A Credali… - Current opinion in chemical …, 2014 - Elsevier
Highlights•HmuUV is the first structure of a heme uptake inner membrane ABC
transporter.•A novel assay was developed to assess in vitro heme uptake for …
transporter.•A novel assay was developed to assess in vitro heme uptake for …
Overcoming the heme paradox: heme toxicity and tolerance in bacterial pathogens
LL Anzaldi, EP Skaar - Infection and immunity, 2010 - Am Soc Microbiol
Virtually all bacterial pathogens require iron to infect vertebrates. The most abundant source
of iron within vertebrates is in the form of heme as a cofactor of hemoproteins. Many …
of iron within vertebrates is in the form of heme as a cofactor of hemoproteins. Many …
Extracellular heme uptake and the challenge of bacterial cell membranes
W Huang, A Wilks - Annual Review of Biochemistry, 2017 - annualreviews.org
Iron is essential for the survival of most bacteria but presents a significant challenge given its
limited bioavailability. Furthermore, the toxicity of iron combined with the need to maintain …
limited bioavailability. Furthermore, the toxicity of iron combined with the need to maintain …
Bacterial heme-transport proteins and their heme-coordination modes
Y Tong, M Guo - Archives of biochemistry and biophysics, 2009 - Elsevier
Efficient iron acquisition is critical for an invading microbe's survival and virulence. Most of
the iron in mammals is incorporated into heme, which can be plundered by certain bacterial …
the iron in mammals is incorporated into heme, which can be plundered by certain bacterial …
Emerging strategies in microbial haem capture: MicroReview
CA Genco, DW Dixon - Molecular microbiology, 2001 - Wiley Online Library
Gram‐negative pathogenic bacteria have evolved novel strategies to obtain iron from host
haem‐sequestering proteins. These include the production of specific outer membrane …
haem‐sequestering proteins. These include the production of specific outer membrane …
Degradation of Heme in Gram-Negative Bacteria: the Product of the hemO Gene of Neisseriae Is a Heme Oxygenase
W Zhu, A Wilks, I Stojiljkovic - Journal of bacteriology, 2000 - Am Soc Microbiol
ABSTRACT A full-length heme oxygenase gene from the gram-negative pathogen Neisseria
meningitidis was cloned and expressed in Escherichia coli. Expression of the enzyme …
meningitidis was cloned and expressed in Escherichia coli. Expression of the enzyme …