Bacterial pathogens require the iron-containing cofactor heme to cause disease. Heme is
essential to the function of hemoproteins, which are involved in energy generation by the …

Covering: 2000–2006 The ability of bacterial pathogens to obtain iron is essential for their
survival, and the expression of such virulence factors is (in part) essential for establishing …

Iron is a transition metal utilized by nearly all forms of life for essential cellular processes,
such as DNA synthesis and cellular respiration. During infection by bacterial pathogens, the …

Bacteria that reside in animal tissues and/or cells must acquire iron from their host. However,
almost all of the host iron is sequestered in iron-containing compounds and proteins, the …

Highlights•HmuUV is the first structure of a heme uptake inner membrane ABC
transporter.•A novel assay was developed to assess in vitro heme uptake for …

Virtually all bacterial pathogens require iron to infect vertebrates. The most abundant source
of iron within vertebrates is in the form of heme as a cofactor of hemoproteins. Many …

Iron is essential for the survival of most bacteria but presents a significant challenge given its
limited bioavailability. Furthermore, the toxicity of iron combined with the need to maintain …

Efficient iron acquisition is critical for an invading microbe's survival and virulence. Most of
the iron in mammals is incorporated into heme, which can be plundered by certain bacterial …

Gram‐negative pathogenic bacteria have evolved novel strategies to obtain iron from host
haem‐sequestering proteins. These include the production of specific outer membrane …

ABSTRACT A full-length heme oxygenase gene from the gram-negative pathogen Neisseria
meningitidis was cloned and expressed in Escherichia coli. Expression of the enzyme …