Dietary administration of berberine or Phellodendron amurense extract inhibits cell cycle progression and lung tumorigenesis

MA James, H Fu, Y Liu, DR Chen… - Molecular …, 2011 - Wiley Online Library
Phellodendron amurense extract is a Chinese herbal remedy that has recently been studied
for its antitumor, antimicrobial and other biological activities. It is previously unknown if these …

p53 cooperates berberine‐induced growth inhibition and apoptosis of non‐small cell human lung cancer cells in vitro and tumor xenograft growth in vivo

SK Katiyar, SM Meeran, N Katiyar… - … in cooperation with the …, 2009 - Wiley Online Library
Berberine has been shown to have anti‐carcinogenic effects. Since p53 is the most
commonly mutated tumor suppressor gene, and a lack of functional p53 is associated with …

Berberine inhibits non‐small cell lung cancer cell growth through repressing DNA repair and replication rather than through apoptosis

L Ni, Z Li, H Ren, L Kong, X Chen… - Clinical and …, 2022 - Wiley Online Library
At present, there are still many problems in the treatment of lung cancer, such as high cost,
side effects and low quality of life. The advantages of traditional Chinese medicine (TCM) in …

Berberine inhibits pulmonary metastasis through down‐regulation of MMP in metastatic B16F‐10 melanoma cells

TP Hamsa, G Kuttan - Phytotherapy Research, 2012 - Wiley Online Library
The present study demonstrated the potential antimetastatic and antiinvasive effect of
berberine using both in vivo mouse lung metastasis and in vitro models. Administration of …

A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs

Y Sun, K Xun, Y Wang, X Chen - Anti-cancer drugs, 2009 - journals.lww.com
Natural products represent a rich reservoir of potential small chemical molecules exhibiting
antiproliferation and anticancer properties. An example is berberine, a protoberberine …

Multi-target potential of berberine as an antineoplastic and antimetastatic agent: a special focus on lung cancer treatment

IT Achi, P Sarbadhikary, BP George, H Abrahamse - Cells, 2022 - mdpi.com
Despite therapeutic advancements, lung cancer remains the principal cause of cancer
mortality in a global scenario. The increased incidence of tumor reoccurrence and …

Different concentrations of berberine result in distinct cellular localization patterns and cell cycle effects in a melanoma cell line

TL Serafim, PJ Oliveira, VA Sardao, E Perkins… - Cancer Chemotherapy …, 2008 - Springer
Purpose Natural products represent a rich reservoir of potential small molecule inhibitors
exhibiting antiproliferative and tumoricidal properties. An example is the isoquinoline …

Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model

YT Ho, JS Yang, CC Lu, JH Chiang, TC Li, JJ Lin… - Phytomedicine, 2009 - Elsevier
Our primary studies showed that berberine induced apoptosis in human tongue cancer SCC-
4 cells in vitro. But there is no report to show berberine inhibited SCC-4 cancer cells in vivo …

The natural alkaloid berberine targets multiple pathways to induce cell death in cultured human colon cancer cells

KNC Murthy, GK Jayaprakasha, BS Patil - European journal of …, 2012 - Elsevier
In the current paper, berberine, an isoquinoline alkaloid, was tested for its chemopreventive
potential in colon cancer (SW480) cells. Berberine inhibited proliferation of colon cancer …

Anticancer effect of berberine based on experimental animal models of various cancers: A systematic review and meta-analysis

J Xu, Y Long, L Ni, X Yuan, N Yu, R Wu, J Tao, Y Zhang - BMC cancer, 2019 - Springer
Background Numerous studies have explored the anti-tumor effect of berberine (BBR), but
little clinical evidence guides the use of BBR in cancer patients. Objectives Our aim was to …