Genital HIV-1 RNA predicts risk of heterosexual HIV-1 transmission

JM Baeten, E Kahle, JR Lingappa… - Science translational …, 2011 - science.org
High plasma HIV-1 RNA concentrations are associated with an increased risk of HIV-1
transmission. Although plasma and genital HIV-1 RNA concentrations are correlated, no …

Lower levels of HIV RNA in semen in HIV-2 compared with HIV-1 infection: implications for differences in transmission

GS Gottlieb, SE Hawes, HD Agne, JE Stern… - Aids, 2006 - journals.lww.com
Results: The mean age of the subjects was 37 and 40 years; mean CD4 cell count was 222
and 276 cells/μl and the mean plasma viral load was 4.7 and 3.0 log 10 copies/ml for HIV-1 …

Estimating the impact of plasma HIV-1 RNA reductions on heterosexual HIV-1 transmission risk

JR Lingappa, JP Hughes, RS Wang, JM Baeten… - PloS one, 2010 - journals.plos.org
Background The risk of sexual transmission of HIV-1 is strongly associated with the level of
HIV-1 RNA in plasma making reduction in HIV-1 plasma levels an important target for HIV-1 …

Higher concentration of HIV RNA in rectal mucosa secretions than in blood and seminal plasma, among men who have sex with men, independent of antiretroviral …

RA Zuckerman, WLH Whittington… - The Journal of …, 2004 - academic.oup.com
High levels of human immunodeficiency virus (HIV) in rectal secretions and semen likely
increase the risk of HIV transmission. HIV-infected men who have sex with men made 2–3 …

Determinants of HIV-1 shedding in the genital tract of women

A Kovacs, SS Wasserman, D Burns, DJ Wright, J Cohn… - The Lancet, 2001 - thelancet.com
Summary Background Plasma HIV-1 RNA concentration has been the best predictor for risk
of heterosexual and perinatal transmission. However, direct contact with HIV-1 present …

HIV transmission risk persists during the first 6 months of antiretroviral therapy

A Mujugira, C Celum, RW Coombs… - JAIDS Journal of …, 2016 - journals.lww.com
Objective: Combination antiretroviral therapy (ART) decreases the risk of sexual HIV
transmission by suppressing blood and genital HIV RNA concentrations. We sought to …

Amplified transmission of HIV-1: comparison of HIV-1 concentrations in semen and blood during acute and chronic infection

CD Pilcher, G Joaki, IF Hoffman, FEA Martinson… - Aids, 2007 - journals.lww.com
Objectives: This study was conducted to compare viral dynamics in blood and semen
between subjects with antibody negative, acute HIV-1 infection and other subjects with later …

Male viral load and heterosexual transmission of HIV-1 subtype E in northern Thailand

S Tovanabutra, V Robison, J Wongtrakul… - JAIDS Journal of …, 2002 - journals.lww.com
We evaluated the association between HIV-1 RNA copies/mL in men and heterosexual
transmission to their female partners among 493 couples in Thailand. Husbands were …

Association between paired plasma and cervicovaginal lavage fluid HIV-1 RNA levels during 36 months

S Cu-Uvin, B Snyder, JI Harwell, J Hogan… - JAIDS Journal of …, 2006 - journals.lww.com
Objective: To determine the patterns and predictors of genital tract HIV-1 RNA levels during
a 36-month period. Methods: HIV-1 RNA levels were measured blood in plasma and the …

Detection and quantification of HIV-1 in semen: identification of a subpopulation of men at high potential risk of viral sexual transmission

A Tachet, E Dulioust, D Salmon, M De Almeida… - Aids, 1999 - journals.lww.com
Background: To assess HIV burden in both acellular and cellular fractions of semen in men
with different levels of blood plasma HIV RNA by a cross-sectional study. Patients: Fifty-two …