[HTML][HTML] Single cell RNA sequencing reveals endothelial cell killing and resolution pathways in experimental malaria-associated acute respiratory distress syndrome

E Pollenus, H Possemiers, S Knoops, F Prenen… - Plos …, 2024 - journals.plos.org
Plasmodium parasites cause malaria, a global health disease that is responsible for more
than 200 million clinical cases and 600 000 deaths each year. Most deaths are caused by …

[HTML][HTML] Experimental models to study the pathogenesis of malaria-associated acute respiratory distress syndrome

SYT Nguee, JWBD Júnior, S Epiphanio… - Frontiers in Cellular …, 2022 - frontiersin.org
Malaria-associated acute respiratory distress syndrome (MA-ARDS) is increasingly gaining
recognition as a severe malaria complication because of poor prognostic outcomes, high …

[HTML][HTML] Blockade of caspase cascade overcomes malaria-associated acute respiratory distress syndrome in mice

MK Sercundes, LS Ortolan, V da Silva Julio… - Cell Death & …, 2022 - nature.com
Malaria is an enormous burden on global health that caused 409,000 deaths in 2019.
Severe malaria can manifest in the lungs, an illness known as acute respiratory distress …

[HTML][HTML] Targeting neutrophils to prevent malaria-associated acute lung injury/acute respiratory distress syndrome in mice

MK Sercundes, LS Ortolan, D Debone… - PLoS …, 2016 - journals.plos.org
Malaria remains one of the greatest burdens to global health, causing nearly 500,000
deaths in 2014. When manifesting in the lungs, severe malaria causes acute lung …

[HTML][HTML] Parasite burden and CD36-mediated sequestration are determinants of acute lung injury in an experimental malaria model

FE Lovegrove, SA Gharib, L Peña-Castillo… - PLoS …, 2008 - journals.plos.org
Although acute lung injury (ALI) is a common complication of severe malaria, little is known
about the underlying molecular basis of lung dysfunction. Animal models have provided …

[HTML][HTML] Host lung microbiota promotes malaria-associated acute respiratory distress syndrome

D Mukherjee, ÂF Chora, JC Lone, RS Ramiro… - Nature …, 2022 - nature.com
Severe malaria can manifest itself with a variety of well-recognized clinical phenotypes that
are highly predictive of death–severe anaemia, coma (cerebral malaria), multiple organ …

[HTML][HTML] Ultrastructure of the lung in a murine model of malaria-associated acute lung injury/acute respiratory distress syndrome

EH Aitken, EM Negri, R Barboza, MRI Lima, JM Álvarez… - Malaria journal, 2014 - Springer
Background The mechanisms through which infection with Plasmodium spp. result in lung
disease are largely unknown. Recently a number of mouse models have been developed to …

[HTML][HTML] Experimental malaria-associated acute respiratory distress syndrome is dependent on the parasite-host combination and coincides with normocyte invasion

L Vandermosten, TT Pham, H Possemiers, S Knoops… - Malaria journal, 2018 - Springer
Background Malaria-associated acute respiratory distress syndrome (MA-ARDS) is a
complication of malaria with a lethality rate of up to 80% despite anti-malarial treatment. It is …

[HTML][HTML] Skeleton binding protein-1-mediated parasite sequestration inhibits spontaneous resolution of malaria-associated acute respiratory distress syndrome

H Possemiers, TT Pham, M Coens, E Pollenus… - PLoS …, 2021 - journals.plos.org
Malaria is a hazardous disease caused by Plasmodium parasites and often results in lethal
complications, including malaria-associated acute respiratory distress syndrome (MA …

[HTML][HTML] Lung endothelial cell antigen cross-presentation to CD8+T cells drives malaria-associated lung injury

C Claser, SYT Nguee, A Balachander… - Nature …, 2019 - nature.com
Malaria-associated acute respiratory distress syndrome (ARDS) and acute lung injury (ALI)
are life-threatening manifestations of severe malaria infections. The pathogenic mechanisms …