The liver is a central organ in the human body, coordinating several key metabolic roles. The
structure of the liver which consists of the distinctive arrangement of hepatocytes, hepatic …

Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global
health. Correlating with liver disease progression, fibrosis is a key factor for liver disease …

Hepatic fibrosis is a dynamic process that occurs as a wound healing response against liver
injury. During fibrosis, crosstalk between parenchymal and non-parenchymal cells …

Liver fibrosis is the pathological process of excessive extracellular matrix deposition after
liver injury and is a precursor to cirrhosis, hepatocellular carcinoma (HCC). It is essentially a …

Highlights•Liver fibrosis is an important health problem associated to morbility and
mortality.•Extensive data have provided knowledge of the major key cellular and molecular …

Hepatic fibrosis is a wound-healing response to chronic liver injury, which if persistent can
lead to cirrhosis and liver failure. Activation of hepatic stellate cells (HSCs), leading to …

The response to injury is one of wound healing and fibrogenesis, which ultimately leads to
fibrosis. The fibrogenic response to injury is a generalized one across virtually all organ …

▪ Abstract Liver fibrosis is the common response to chronic liver injury, ultimately leading to
cirrhosis and its complications, portal hypertension, liver failure, and hepatocellular …

T has been exciting progress in our understand-ing of hepatic fibrosis in the past
decade. Hepatic fibrosis, or the deposition of extracellular matrix, was once viewed as a …

Liver fibrosis is an abnormal wound repair response caused by a variety of chronic liver
injuries, which is characterized by over-deposition of diffuse extracellular matrix (ECM) and …